000302804 001__ 302804
000302804 005__ 20250716114046.0
000302804 0247_ $$2doi$$a10.1038/s44303-025-00081-3
000302804 0247_ $$2pmid$$apmid:40604117
000302804 0247_ $$2pmc$$apmc:PMC12118740
000302804 037__ $$aDKFZ-2025-01344
000302804 041__ $$aEnglish
000302804 1001_ $$aGottwald, Wolfgang$$b0
000302804 245__ $$aTemperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry.
000302804 260__ $$a[London]$$b[Nature Publishing Group UK]$$c2025
000302804 3367_ $$2DRIVER$$aarticle
000302804 3367_ $$2DataCite$$aOutput Types/Journal article
000302804 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1752656212_10338
000302804 3367_ $$2BibTeX$$aARTICLE
000302804 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000302804 3367_ $$00$$2EndNote$$aJournal Article
000302804 520__ $$aThe chemical shift of many molecules changes with temperature, which enables non-invasive magnetic resonance imaging (MRI) thermometry. Hyperpolarization methods increase the inherently low 13C MR signal. The commonly-used hyperpolarized probe [1-13C]pyruvate, and its metabolic product [1-13C]lactate, exhibit temperature and concentration dependent chemical shift changes that have not previously been reported. These effects were characterized at 7 T and 11.7 T in vitro and applied for in vivo thermometry both preclinically at 7 T and to human data at 3 T. Apparent temperature values from mouse abdomen and brain were similar to rectally measured temperature. Human brain and kidney apparent temperatures from 13C MRSI were lower than known physiological temperatures, suggesting that additional effects may currently limit the use of this method for determining absolute temperature in humans. The temperature dependent chemical shift changes also have implications for sequence design and for in vitro studies with hyperpolarized pyruvate.
000302804 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000302804 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000302804 7001_ $$aNagel, Luca$$b1
000302804 7001_ $$aSkinner, Jason G$$b2
000302804 7001_ $$aGrashei, Martin$$b3
000302804 7001_ $$aSühnel, Sandra$$b4
000302804 7001_ $$aSetzer, Nadine$$b5
000302804 7001_ $$aEisenreich, Wolfgang$$b6
000302804 7001_ $$aMcLean, Mary A$$b7
000302804 7001_ $$aGallagher, Ferdia A$$b8
000302804 7001_ $$aPark, Jae Mo$$b9
000302804 7001_ $$aAhmadova, Zumrud$$b10
000302804 7001_ $$aGierse, Martin$$b11
000302804 7001_ $$aKaraali, Senay$$b12
000302804 7001_ $$aKnecht, Stephan$$b13
000302804 7001_ $$aSchwartz, Ilai$$b14
000302804 7001_ $$aHeid, Irina$$b15
000302804 7001_ $$aTopping, Geoffrey J$$b16
000302804 7001_ $$avan Heijster, Frits H A$$b17
000302804 7001_ $$0P:(DE-HGF)0$$aSchilling, Franz$$b18
000302804 773__ $$0PERI:(DE-600)3179899-8$$a10.1038/s44303-025-00081-3$$gVol. 3, no. 1, p. 19$$n1$$p19$$tnpj imaging$$v3$$x2948-197X$$y2025
000302804 909CO $$ooai:inrepo02.dkfz.de:302804$$pVDB
000302804 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b18$$kDKFZ
000302804 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000302804 9141_ $$y2025
000302804 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-31
000302804 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-07-02T09:43:42Z
000302804 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-07-02T09:43:42Z
000302804 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2024-07-02T09:43:42Z
000302804 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2024-07-02T09:43:42Z
000302804 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-31
000302804 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-31
000302804 9201_ $$0I:(DE-He78)MU01-20160331$$kMU01$$lDKTK Koordinierungsstelle München$$x0
000302804 980__ $$ajournal
000302804 980__ $$aVDB
000302804 980__ $$aI:(DE-He78)MU01-20160331
000302804 980__ $$aUNRESTRICTED