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@ARTICLE{Gottwald:302804,
      author       = {W. Gottwald and L. Nagel and J. G. Skinner and M. Grashei
                      and S. Sühnel and N. Setzer and W. Eisenreich and M. A.
                      McLean and F. A. Gallagher and J. M. Park and Z. Ahmadova
                      and M. Gierse and S. Karaali and S. Knecht and I. Schwartz
                      and I. Heid and G. J. Topping and F. H. A. van Heijster and
                      F. Schilling$^*$},
      title        = {{T}emperature dependent chemical shifts of pyruvate and
                      lactate enable in vivo hyperpolarized 13{C} {MRSI}
                      thermometry.},
      journal      = {npj imaging},
      volume       = {3},
      number       = {1},
      issn         = {2948-197X},
      address      = {[London]},
      publisher    = {[Nature Publishing Group UK]},
      reportid     = {DKFZ-2025-01344},
      pages        = {19},
      year         = {2025},
      abstract     = {The chemical shift of many molecules changes with
                      temperature, which enables non-invasive magnetic resonance
                      imaging (MRI) thermometry. Hyperpolarization methods
                      increase the inherently low 13C MR signal. The commonly-used
                      hyperpolarized probe [1-13C]pyruvate, and its metabolic
                      product [1-13C]lactate, exhibit temperature and
                      concentration dependent chemical shift changes that have not
                      previously been reported. These effects were characterized
                      at 7 T and 11.7 T in vitro and applied for in vivo
                      thermometry both preclinically at 7 T and to human data at 3
                      T. Apparent temperature values from mouse abdomen and brain
                      were similar to rectally measured temperature. Human brain
                      and kidney apparent temperatures from 13C MRSI were lower
                      than known physiological temperatures, suggesting that
                      additional effects may currently limit the use of this
                      method for determining absolute temperature in humans. The
                      temperature dependent chemical shift changes also have
                      implications for sequence design and for in vitro studies
                      with hyperpolarized pyruvate.},
      cin          = {MU01},
      cid          = {I:(DE-He78)MU01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40604117},
      pmc          = {pmc:PMC12118740},
      doi          = {10.1038/s44303-025-00081-3},
      url          = {https://inrepo02.dkfz.de/record/302804},
}