%0 Journal Article
%A Klostermann, A.
%A Debertshäuser, T.
%A Benary, M.
%A Biernath, N.
%A Erber, B.
%A Tahbaz, R.
%A Möbs, M.
%A Joosten, M.
%A Schmitt, W. D.
%A Kim, T.
%A Jelas, I.
%A Chai, L.
%A Jegodka, Y.
%A Keller, U.
%A Beule, D.
%A Ochsenreither, S.
%A De Santis, M.
%A Schlomm, T.
%A Keilholz, Ulrich
%A Knödler, M.
%A Rieke, Damian
%T Implementation and outcome of personalized treatment strategies in advanced genitourinary cancers.
%J ESMO open
%V 10
%N 7
%@ 2059-7029
%C [London]
%I Elsevier
%M DKFZ-2025-01346
%P 105497
%D 2025
%X Outcome is dismal in patients with advanced genitourinary (GU) cancers refractory to standard treatments. Molecular analyses and subsequent discussion of cases in specialized molecular tumor boards (MTBs) are increasingly incorporated into clinical management to facilitate personalized treatment. Data on this approach are lacking for GU malignancies.We conducted a retrospective analysis of patients with GU cancers discussed in the MTB at the Charité between 2016 and 2023. Ethics approval was obtained for prospective follow-up of patients after written informed consent and for retrospective data analysis. Clinical benefit was defined as complete response (CR), partial response (PR) or stable disease (SD) >6 months or a progression-free survival (PFS) ratio between molecularly matched therapy (MMT) and previous non-MMT >1.3. Outcome was assessed by the investigators.Among 126 identified MTB patients, most patients had a rare tumor type (n = 59), followed by adenocarcinoma of the prostate (n = 45), urothelial carcinoma (n = 17) and clear-cell renal carcinoma (n = 5). Molecular profiling included immunohistochemistry (n = 80), panel sequencing (n = 110) and/or whole-exome/-transcriptome sequencing (n = 21). Eleven patients died before the final MTB discussion. At least one treatment option for MMT was identified for 78/115 patients (68
%K genitourinary cancer (Other)
%K molecular tumor board (Other)
%K precision oncology (Other)
%K real-world data (Other)
%K targeted therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40602108
%R 10.1016/j.esmoop.2025.105497
%U https://inrepo02.dkfz.de/record/302806