TY  - JOUR
AU  - Leypoldt, Lisa B
AU  - Guo, Linlin
AU  - Besemer, Britta
AU  - Hänel, Mathias
AU  - Raab, Marc-S
AU  - Mann, Christoph
AU  - Michel, Christian S
AU  - Reinhardt, Hans Christian
AU  - Blau, Igor Wolfgang
AU  - Görner, Martin
AU  - Ko, Yon-Dschun
AU  - de Wit, Maike
AU  - Salwender, Hans
AU  - Scheid, Christof
AU  - Graeven, Ullrich
AU  - Peceny, Rudolf
AU  - Staib, Peter
AU  - Dieing, Annette
AU  - Goldschmidt, Hartmut
AU  - Bokemeyer, Carsten
AU  - Zeller, Tanja
AU  - Westermann, Dirk
AU  - Weisel, Katja C
AU  - Twerenbold, Raphael
AU  - Beitzen-Heineke, Antonia
TI  - Cardiac biomarkers for risk stratification in newly diagnosed high-risk multiple myeloma in the GMMG-CONCEPT trial.
JO  - Cardio-Oncology
VL  - 11
IS  - 1
SN  - 2057-3804
CY  - [London]
PB  - BioMed Central
M1  - DKFZ-2025-01348
SP  - 63
PY  - 2025
AB  - Cardiovascular adverse events (CVAE) are clinically relevant side effects during treatment with the proteasome inhibitor carfilzomib. We investigated the predictive value of cardiac biomarkers for onset of CVAE in patients with newly diagnosed high-risk multiple myeloma treated with isatuximab, carfilzomib, lenalidomide, and dexamethasone in the GMMG-CONCEPT study (NCT03104842). Patients included in this prospective, multicenter correlative study were eligible if a serum sample before treatment initiation and at ≥ 1 later study time point were available. N-terminal pro-b-type natriuretic peptide (NT-proBNP) and high-sensitive Troponin I (hsTropI) were measured using immunoassays. Time-to-event analyses were performed using Kaplan-Meier estimators and log-rank test was used for statistical analysis. Among 126 patients included in this study, 40 reported incident CVAE. No significant differences were observed for age, sex, cardiovascular risk factors and cardiovascular comorbidities between patients who experienced CVAE compared to patients without CVAE. NT-proBNP levels were elevated at baseline in 96 (76
LB  - PUB:(DE-HGF)16
C6  - pmid:40611354
C2  - pmc:PMC12224601
DO  - DOI:10.1186/s40959-025-00358-x
UR  - https://inrepo02.dkfz.de/record/302808
ER  -