TY  - JOUR
AU  - Behzadi, Sophie T
AU  - Moser, Rebecca
AU  - Düsberg, Mathias
AU  - Aigner, Maximilian
AU  - Nano, Jana
AU  - Kiesl, Sophia
AU  - Lammert, Jacqueline
AU  - Klein, Evelyn
AU  - Schmidt, Georg P
AU  - Kiechle, Marion
AU  - Huber, Thomas
AU  - Corradini, Stefanie
AU  - Combs, Stephanie E
AU  - Borm, Kai J
TI  - Partial breast irradiation after sentinel lymph node biopsy omission: Is it a valid alternative to whole breast Irradiation? Analysis of the dose to the sentinel lymph node region during whole breast irradiation vs. partial breast irradiation.
JO  - The breast
VL  - 82
SN  - 0960-9776
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2025-01352
SP  - 104523
PY  - 2025
AB  - Sentinel lymph node biopsy (SLNB) can be safely omitted in selected early-stage, clinically node-negative breast cancer (BC) patients. While these patients are also candidates for partial breast irradiation (PBI), the dosimetric effects of PBI on the sentinel lymph node region (SLNs) and axillary levels remain unclear.In this study, SLNs were identified and contoured in 100 BC patients using pre- and postoperative imaging. Axillary levels were contoured following ESTRO guidelines. Dose distribution to the SLN (n = 9000 data points) and axillary levels (n = 270 data points) were analyzed for whole breast irradiation (WBI) and PBI across different techniques (3D-conformal radiation therapy [3D-CRT] vs. volumetric modulated arc therapy [VMAT]), deep inspiration breath-hold [DIBH] vs. free breathing [FB]), and anatomical variations (breast size, tumor site, and upper breast border).WBI provided full therapeutic dose coverage (>95 
KW  - Incidental nodal irradiation (Other)
KW  - Low-risk breast cancer (Other)
KW  - Partial breast irradiation (Other)
KW  - Sentinel lymph node biopsy omission (Other)
KW  - Whole breast irradiation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40609502
DO  - DOI:10.1016/j.breast.2025.104523
UR  - https://inrepo02.dkfz.de/record/302812
ER  -