%0 Journal Article
%A Jabbarli, Leyla
%A Lever, Mael
%A Kiefer, Tobias
%A Biewald, Eva
%A Rating, Philipp
%A Guberina, Maja
%A Flühs, Dirk
%A Guberina, Nika
%A Jabbarli, Ramazan
%A Stuschke, Martin
%A Bechrakis, Nikolaos E
%A Tsimpaki, Theodora
%A Fiorentzis, Miltiadis
%T Long-term outcome after treatment of large uveal melanoma.
%J International ophthalmology
%V 45
%N 1
%@ 0165-5701
%C Dordrecht
%I Springer Science + Business Media B.V.
%M DKFZ-2025-01362
%P 279
%D 2025
%X The management of large uveal melanomas (UM) remains a significant challenge. Treatment options include radiotherapy alone or in combination with surgical interventions. This study evaluates the long-term outcomes of patients with large UM, focusing on the impact of different treatment strategies.All consecutive patients with large UM treated at our institution primarily with an eye-salvaging approach-either bi-nuclide plaque brachytherapy (BNPB) or endoresection (ER) following neoadjuvant irradiation-between January 2014 and December 2020 were included in this study. Tumors with a thickness greater than 7.0 mm that were not suitable for ruthenium-106 plaque brachytherapy were classified as large. The primary study endpoints were the incidence of legal blindness of the affected eye at 12 and 36 months, as well as eye preservation and local tumor control at 36 months.Overall, 194 patients underwent ER, while 204 received BNPB. At 12 and 36 months, legal blindness was documented in 25.5
%K Humans
%K Melanoma: radiotherapy
%K Melanoma: diagnosis
%K Melanoma: therapy
%K Melanoma: pathology
%K Uveal Neoplasms: radiotherapy
%K Uveal Neoplasms: therapy
%K Uveal Neoplasms: diagnosis
%K Uveal Neoplasms: pathology
%K Male
%K Female
%K Uveal Melanoma
%K Brachytherapy: methods
%K Middle Aged
%K Aged
%K Retrospective Studies
%K Follow-Up Studies
%K Treatment Outcome
%K Time Factors
%K Adult
%K Aged, 80 and over
%K Brachytherapy (Other)
%K Endoresection (Other)
%K Enucleation (Other)
%K Large uveal melanoma (Other)
%K Local recurrence (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40627056
%2 pmc:PMC12238149
%R 10.1007/s10792-025-03624-0
%U https://inrepo02.dkfz.de/record/302822