TY  - JOUR
AU  - Jabbarli, Leyla
AU  - Lever, Mael
AU  - Kiefer, Tobias
AU  - Biewald, Eva
AU  - Rating, Philipp
AU  - Guberina, Maja
AU  - Flühs, Dirk
AU  - Guberina, Nika
AU  - Jabbarli, Ramazan
AU  - Stuschke, Martin
AU  - Bechrakis, Nikolaos E
AU  - Tsimpaki, Theodora
AU  - Fiorentzis, Miltiadis
TI  - Long-term outcome after treatment of large uveal melanoma.
JO  - International ophthalmology
VL  - 45
IS  - 1
SN  - 0165-5701
CY  - Dordrecht
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2025-01362
SP  - 279
PY  - 2025
AB  - The management of large uveal melanomas (UM) remains a significant challenge. Treatment options include radiotherapy alone or in combination with surgical interventions. This study evaluates the long-term outcomes of patients with large UM, focusing on the impact of different treatment strategies.All consecutive patients with large UM treated at our institution primarily with an eye-salvaging approach-either bi-nuclide plaque brachytherapy (BNPB) or endoresection (ER) following neoadjuvant irradiation-between January 2014 and December 2020 were included in this study. Tumors with a thickness greater than 7.0 mm that were not suitable for ruthenium-106 plaque brachytherapy were classified as large. The primary study endpoints were the incidence of legal blindness of the affected eye at 12 and 36 months, as well as eye preservation and local tumor control at 36 months.Overall, 194 patients underwent ER, while 204 received BNPB. At 12 and 36 months, legal blindness was documented in 25.5
KW  - Humans
KW  - Melanoma: radiotherapy
KW  - Melanoma: diagnosis
KW  - Melanoma: therapy
KW  - Melanoma: pathology
KW  - Uveal Neoplasms: radiotherapy
KW  - Uveal Neoplasms: therapy
KW  - Uveal Neoplasms: diagnosis
KW  - Uveal Neoplasms: pathology
KW  - Male
KW  - Female
KW  - Uveal Melanoma
KW  - Brachytherapy: methods
KW  - Middle Aged
KW  - Aged
KW  - Retrospective Studies
KW  - Follow-Up Studies
KW  - Treatment Outcome
KW  - Time Factors
KW  - Adult
KW  - Aged, 80 and over
KW  - Brachytherapy (Other)
KW  - Endoresection (Other)
KW  - Enucleation (Other)
KW  - Large uveal melanoma (Other)
KW  - Local recurrence (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40627056
C2  - pmc:PMC12238149
DO  - DOI:10.1007/s10792-025-03624-0
UR  - https://inrepo02.dkfz.de/record/302822
ER  -