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@ARTICLE{BoehmSturm:302823,
      author       = {P. Boehm-Sturm and P. Schuenke and M. Foddis and S. Mueller
                      and S. P. Koch and D. J. Beard and P. Holloway and A.
                      Mottahedin and L. Schröder$^*$ and A. M. Buchan and P.
                      Mergenthaler},
      title        = {2-deoxy-{D}-glucose chemical exchange-sensitive spin-lock
                      {MRI} of cerebral glucose metabolism after transient focal
                      stroke in the rat.},
      journal      = {Journal of cerebral blood flow $\&$ metabolism},
      volume       = {nn},
      issn         = {0271-678X},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DKFZ-2025-01363},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Rapid breakdown of cerebral glucose metabolism is a
                      hallmark in stroke pathology. Metabolic activity delineates
                      the penumbra from the infarct core, representing tissue that
                      is potentially salvageable by therapeutic interventions.
                      Tools to image dynamics of glucose and its spatial
                      distribution could provide biomarkers of disease severity
                      and of the success of therapeutic interventions. Here, we
                      developed a new protocol to measure glucose transport and
                      metabolism in a rat model of stroke using chemical
                      exchange-sensitive spin-lock (CESL) MRI of the glucose
                      analogue 2-deoxy-D-glucose (2DG). We further implemented a
                      protocol that combines 2DG-CESL-MRI with perfusion and
                      diffusion MRI to relate this new signal to established
                      definitions of hypoperfused tissue, cytotoxic edema and the
                      penumbra. We found that 2DG-CESL-MRI provides a biomarker of
                      disturbed glucose transport and metabolism after stroke with
                      high effect size. This is the first study to investigate
                      CESL MRI of 2DG in the context of transport and metabolism
                      imaging in rodent stroke.},
      keywords     = {2-Deoxy-D-glucose (Other) / CESL MRI (Other) / MCAO (Other)
                      / glucose metabolism (Other) / stroke (Other)},
      cin          = {E280 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)E280-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40626496},
      pmc          = {pmc:PMC12237932},
      doi          = {10.1177/0271678X251355049},
      url          = {https://inrepo02.dkfz.de/record/302823},
}