%0 Journal Article
%A Piazena, Helmut
%A Vaupel, Peter
%T Hyperhydration of breast and skin cancers: effects on thermophysical tissue properties in clinical hyperthermia with water-filtered infrared-A radiation (wIRA) - an updated review.
%J International journal of hyperthermia and thermal therapies
%V 42
%N 1
%@ 0265-6736
%C London
%I Informa UK Limited
%M DKFZ-2025-01369
%P 2519352
%D 2025
%X Water contents (Cw) of soft tissues are different and influence (a) the absorption of water-filtered infrared-A radiation (wIRA) used in superficial hyperthermia, (b) key parameters of the Pennes' bioheat transfer equation, and (c) characteristics of heat exchange within and between tissues.The effect of Cw on these parameters has been quantified for normal skin, female breast and corresponding malignancies with Cw values up to ≈ 1.6 times higher.Literature data on spectral absorption and reduced scattering coefficient, density, specific heat capacity, thermal conductivity, diffusivity and effusivity of normal tissues and malignancies have been correlated with respective tissue water contents. Published in vivo data on wIRA-transmittance in human skin and underlying muscle have been experimentally extended to depths up to 11 mm.On average, the absorption of wIRA and the thermal tissue parameters increased linearly with Cw. Mean wIRA-penetration depth reached ≈ 2.9 mm at Cw ≈ 70 wt.
%K Humans
%K Breast Neoplasms: therapy
%K Infrared Rays: therapeutic use
%K Female
%K Hyperthermia, Induced: methods
%K Skin Neoplasms: therapy
%K Water
%K Thermal Conductivity
%K Hyperhydration of cancers (Other)
%K Pennes’ heat transfer equation (Other)
%K superficial hyperthermia (Other)
%K thermophysical tissue properties (Other)
%K wIRA-heating (Other)
%K Water (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40641226
%R 10.1080/02656736.2025.2519352
%U https://inrepo02.dkfz.de/record/302829