TY  - JOUR
AU  - Piazena, Helmut
AU  - Vaupel, Peter
TI  - Hyperhydration of breast and skin cancers: effects on thermophysical tissue properties in clinical hyperthermia with water-filtered infrared-A radiation (wIRA) - an updated review.
JO  - International journal of hyperthermia and thermal therapies
VL  - 42
IS  - 1
SN  - 0265-6736
CY  - London
PB  - Informa UK Limited
M1  - DKFZ-2025-01369
SP  - 2519352
PY  - 2025
AB  - Water contents (Cw) of soft tissues are different and influence (a) the absorption of water-filtered infrared-A radiation (wIRA) used in superficial hyperthermia, (b) key parameters of the Pennes' bioheat transfer equation, and (c) characteristics of heat exchange within and between tissues.The effect of Cw on these parameters has been quantified for normal skin, female breast and corresponding malignancies with Cw values up to ≈ 1.6 times higher.Literature data on spectral absorption and reduced scattering coefficient, density, specific heat capacity, thermal conductivity, diffusivity and effusivity of normal tissues and malignancies have been correlated with respective tissue water contents. Published in vivo data on wIRA-transmittance in human skin and underlying muscle have been experimentally extended to depths up to 11 mm.On average, the absorption of wIRA and the thermal tissue parameters increased linearly with Cw. Mean wIRA-penetration depth reached ≈ 2.9 mm at Cw ≈ 70 wt.
KW  - Humans
KW  - Breast Neoplasms: therapy
KW  - Infrared Rays: therapeutic use
KW  - Female
KW  - Hyperthermia, Induced: methods
KW  - Skin Neoplasms: therapy
KW  - Water
KW  - Thermal Conductivity
KW  - Hyperhydration of cancers (Other)
KW  - Pennes’ heat transfer equation (Other)
KW  - superficial hyperthermia (Other)
KW  - thermophysical tissue properties (Other)
KW  - wIRA-heating (Other)
KW  - Water (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40641226
DO  - DOI:10.1080/02656736.2025.2519352
UR  - https://inrepo02.dkfz.de/record/302829
ER  -