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@ARTICLE{Piazena:302829,
      author       = {H. Piazena and P. Vaupel$^*$},
      title        = {{H}yperhydration of breast and skin cancers: effects on
                      thermophysical tissue properties in clinical hyperthermia
                      with water-filtered infrared-{A} radiation (w{IRA}) - an
                      updated review.},
      journal      = {International journal of hyperthermia and thermal
                      therapies},
      volume       = {42},
      number       = {1},
      issn         = {0265-6736},
      address      = {London},
      publisher    = {Informa UK Limited},
      reportid     = {DKFZ-2025-01369},
      pages        = {2519352},
      year         = {2025},
      abstract     = {Water contents (Cw) of soft tissues are different and
                      influence (a) the absorption of water-filtered infrared-A
                      radiation (wIRA) used in superficial hyperthermia, (b) key
                      parameters of the Pennes' bioheat transfer equation, and (c)
                      characteristics of heat exchange within and between
                      tissues.The effect of Cw on these parameters has been
                      quantified for normal skin, female breast and corresponding
                      malignancies with Cw values up to ≈ 1.6 times
                      higher.Literature data on spectral absorption and reduced
                      scattering coefficient, density, specific heat capacity,
                      thermal conductivity, diffusivity and effusivity of normal
                      tissues and malignancies have been correlated with
                      respective tissue water contents. Published in vivo data on
                      wIRA-transmittance in human skin and underlying muscle have
                      been experimentally extended to depths up to 11 mm.On
                      average, the absorption of wIRA and the thermal tissue
                      parameters increased linearly with Cw. Mean wIRA-penetration
                      depth reached ≈ 2.9 mm at Cw ≈ 70 $wt.\%.$ While
                      specific heat capacities, thermal conductivities, thermal
                      diffusivities and thermal effusivities for melanoma and
                      breast cancer exceeded those of corresponding normal
                      tissues, heat capacities of both malignancies differed only
                      slightly compared to the surrounding normal tissues. Despite
                      small Cw values, maxima of absorbance coupled with low heat
                      capacity and thermal conductivity occurred in the
                      subcutaneous tissues.These data indicate high efficacy of
                      superficial wIRA-hyperthermia in clinical oncology when
                      exposed to composite tissues with highly variable water and
                      fat contents. Continuous monitoring of tissue temperature
                      during irradiation is recommended to prevent hot spots and
                      to ensure therapeutically relevant temperature fields.},
      subtyp        = {Review Article},
      keywords     = {Humans / Breast Neoplasms: therapy / Infrared Rays:
                      therapeutic use / Female / Hyperthermia, Induced: methods /
                      Skin Neoplasms: therapy / Water / Thermal Conductivity /
                      Hyperhydration of cancers (Other) / Pennes’ heat transfer
                      equation (Other) / superficial hyperthermia (Other) /
                      thermophysical tissue properties (Other) / wIRA-heating
                      (Other) / Water (NLM Chemicals)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40641226},
      doi          = {10.1080/02656736.2025.2519352},
      url          = {https://inrepo02.dkfz.de/record/302829},
}