%0 Journal Article
%A Akeret, Kevin
%A Padevit, Luis
%A Reifenberger, Guido
%A von Deimling, Andreas
%A Weller, Michael
%A Le Rhun, Emilie
%T Anatomic Staging of H3 G34-Mutant Diffuse Hemispheric Glioma.
%J Neurology
%V 105
%N 3
%@ 0028-3878
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DKFZ-2025-01375
%P e213861
%D 2025
%X H3 G34-mutant diffuse hemispheric gliomas are rare, aggressive primary brain tumors predominantly affecting young patients. We investigated the prognostic value of anatomic staging (AS)-a system previously validated in adult-type diffuse gliomas-in this molecularly distinct tumor type.Patients from an international cohort with H3 G34-mutant gliomas underwent AS based on pretreatment imaging, performed independently by 2 raters blinded to clinical outcomes. Inter-rater reliability was evaluated using Cohen kappa. Kaplan-Meier curves and Cox proportional hazards models-unadjusted and adjusted for sex, extent of resection, and O6-methylguanine DNA-methyltransferase (MGMT) status-were used to analyze overall survival across stages.Thirty-seven patients were included (median age 22 years; 54
%K Humans
%K Female
%K Male
%K Glioma: genetics
%K Glioma: pathology
%K Glioma: diagnostic imaging
%K Glioma: mortality
%K Brain Neoplasms: genetics
%K Brain Neoplasms: pathology
%K Brain Neoplasms: diagnostic imaging
%K Brain Neoplasms: mortality
%K Adult
%K Young Adult
%K Mutation: genetics
%K Histones: genetics
%K Neoplasm Staging
%K Adolescent
%K Middle Aged
%K Prognosis
%K Cohort Studies
%K Kaplan-Meier Estimate
%K DNA Modification Methylases: genetics
%K Histones (NLM Chemicals)
%K DNA Modification Methylases (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40638885
%R 10.1212/WNL.0000000000213861
%U https://inrepo02.dkfz.de/record/302835