TY  - JOUR
AU  - Akeret, Kevin
AU  - Padevit, Luis
AU  - Reifenberger, Guido
AU  - von Deimling, Andreas
AU  - Weller, Michael
AU  - Le Rhun, Emilie
TI  - Anatomic Staging of H3 G34-Mutant Diffuse Hemispheric Glioma.
JO  - Neurology
VL  - 105
IS  - 3
SN  - 0028-3878
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DKFZ-2025-01375
SP  - e213861
PY  - 2025
AB  - H3 G34-mutant diffuse hemispheric gliomas are rare, aggressive primary brain tumors predominantly affecting young patients. We investigated the prognostic value of anatomic staging (AS)-a system previously validated in adult-type diffuse gliomas-in this molecularly distinct tumor type.Patients from an international cohort with H3 G34-mutant gliomas underwent AS based on pretreatment imaging, performed independently by 2 raters blinded to clinical outcomes. Inter-rater reliability was evaluated using Cohen kappa. Kaplan-Meier curves and Cox proportional hazards models-unadjusted and adjusted for sex, extent of resection, and O6-methylguanine DNA-methyltransferase (MGMT) status-were used to analyze overall survival across stages.Thirty-seven patients were included (median age 22 years; 54
KW  - Humans
KW  - Female
KW  - Male
KW  - Glioma: genetics
KW  - Glioma: pathology
KW  - Glioma: diagnostic imaging
KW  - Glioma: mortality
KW  - Brain Neoplasms: genetics
KW  - Brain Neoplasms: pathology
KW  - Brain Neoplasms: diagnostic imaging
KW  - Brain Neoplasms: mortality
KW  - Adult
KW  - Young Adult
KW  - Mutation: genetics
KW  - Histones: genetics
KW  - Neoplasm Staging
KW  - Adolescent
KW  - Middle Aged
KW  - Prognosis
KW  - Cohort Studies
KW  - Kaplan-Meier Estimate
KW  - DNA Modification Methylases: genetics
KW  - Histones (NLM Chemicals)
KW  - DNA Modification Methylases (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40638885
DO  - DOI:10.1212/WNL.0000000000213861
UR  - https://inrepo02.dkfz.de/record/302835
ER  -