TY  - JOUR
AU  - Bigge, Jan Carl
AU  - Bendrich, Stephanie
AU  - Treiber, Hannes
AU  - Aydilek, Enver
AU  - Brökers, Nils
AU  - Wulf, Gerald Georg
AU  - Zwerenz, Carla Marie
AU  - Anczykowski, Mahalia Zoe
AU  - Donath, Sandra
AU  - El Shafie, Rami A
AU  - von Diest, Lisa-Antonia
AU  - Oelmann, Jan Tobias
AU  - Schirmer, Markus Anton
AU  - Dröge, Leif Hendrik
AU  - Leu, Martin
AU  - Chapuy, Björn
AU  - Rieken, Stefan
AU  - Guhlich, Manuel
TI  - Clinical Predictors and Recurrence Characteristics Following Radiotherapy for Primary Central Nervous System Lymphoma: A Retrospective Cohort Study.
JO  - Cancers
VL  - 17
IS  - 13
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2025-01381
SP  - 2176
PY  - 2025
AB  - Background/Objectives: Primary central nervous system lymphoma (PCNSL) is a rare but aggressive tumor, primarily affecting elderly patients. Radiotherapy (RT) remains an important treatment option, particularly for patients who are ineligible for systemic chemotherapy. This study aims to identify prognostic factors and evaluate recurrence patterns in a real-world cohort of PCNSL patients treated with RT. Methods: We retrospectively analyzed 64 PCNSL patients treated with radiotherapy at our institution between 2000 and 2022. Clinical characteristics, treatment details, and outcomes were collected by chart review. Overall survival (OS) was analyzed using Kaplan-Meier and Cox regression methods. Recurrence patterns were assessed based on available post-treatment imaging. Results: Median patient age was 71 years (range: 31-83); 53.1
KW  - PCNSL (Other)
KW  - overall survival (Other)
KW  - primary central nervous system lymphoma (Other)
KW  - prognostic factors (Other)
KW  - radiotherapy (Other)
KW  - real-world-analysis (Other)
KW  - seizures (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40647475
C2  - pmc:PMC12248931
DO  - DOI:10.3390/cancers17132176
UR  - https://inrepo02.dkfz.de/record/302841
ER  -