TY  - JOUR
AU  - Obermüller, Dominik
AU  - Berger, Karin
AU  - Klamroth, Robert
AU  - Kleppisch, Maria
AU  - Rauchensteiner, Stephan
AU  - Ecke, Ines
AU  - Hermann, Sandra
AU  - Pawlowska-Phelan, Dorota
AU  - Häckl, Dennis
AU  - Kisser, Agnes
TI  - Epidemiology, Health Care Resource Utilization, and Costs of Hemophilia A and B by Treatment Regimen: A Retrospective Analysis of German Claims Data from 2016 to 2021.
JO  - Hämostaseologie
VL  - nn
SN  - 0720-9355
CY  - Stuttgart
PB  - Thieme
M1  - DKFZ-2025-01387
SP  - nn
PY  - 2025
N1  - epub
AB  - In Germany, hemophilia patients with a severe bleeding phenotype receive lifelong prophylactic treatment with intravenous concentrated factor VIII (FVIII) or IX (FIX) to prevent bleeding events. To assess the economic value of emerging treatment options, studies describing the economic burden of hemophilia under the current standard of care in Germany are needed.This study classified hemophilia A (HA) and B (HB) patients by treatment regimen in administrative claims data to examine the real-world economic burden of Hemophilia in Germany from 2016 to 2021.Hemophilia patients were identified in InGef statutory health insurance claims data via ICD-10 codes D66 (HA) and D67 (HB) in combination with one or more claims for hemophilia-related medication.Each patient's factor regimen was classified as either indicative of a severe phenotype needing prophylaxis or a non-severe phenotype treated on demand using a classification threshold of 100,000 International Units (IU) FVIII/year (HA) and 80,000 IU FIX/year (HB). Health care resource utilization and cost outcomes were captured for each study year.Male prevalence per 100,000 ranged from 6.39 to 7.81 (HA) and 1.26 to 1.89 (HB), with 43 to 53
LB  - PUB:(DE-HGF)16
C6  - pmid:40659341
DO  - DOI:10.1055/a-2558-9886
UR  - https://inrepo02.dkfz.de/record/302847
ER  -