TY  - JOUR
AU  - Thong, Melissa
AU  - Doege, Daniela
AU  - Koch-Gallenkamp, Lena
AU  - Bertram, Heike
AU  - Eberle, Andrea
AU  - Holleczek, Bernd
AU  - Nennecke, Alice
AU  - Waldmann, Annika
AU  - Zeissig, Sylke Ruth
AU  - Pritzkuleit, Ron
AU  - Brähler, Elmar
AU  - Brenner, Hermann
AU  - Arndt, Volker
TI  - Fatigue in long-term cancer survivors: prevalence, associated factors, and mortality. A prospective population-based study.
JO  - British journal of cancer
VL  - nn
SN  - 0007-0920
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2025-01395
SP  - nn
PY  - 2025
N1  - #EA:C070#EA:C071#LA:C070#LA:C071# / epub
AB  - We compared fatigue severity in breast, prostate or colorectal cancer survivors 5-16 years post-diagnosis with cancer-free controls, and examined factors associated with fatigue and its association with all-cause mortality in survivors.Participants of the CAncEr Survivorship - A multi-Regional (CAESAR) study completed the Fatigue Assessment Questionnaire (FAQ) between 2009 and 2011. The FAQ assesses affective, cognitive, and physical fatigue, and sleep problems. We derived the odds of fatigue using logistic regression with the 75th percentile of population norms as the cut-off. All-cause mortality (up to end 2021) was estimated using Cox regression models.The sample comprised 6057 survivors, of whom approximately one-third reported affective, cognitive, or physical fatigue. Demographic (age, relationship), clinical (chemotherapy), comorbidity (depression), lifestyle, and psychological factors were associated with higher odds of fatigue symptoms and total fatigue. Fatigue symptoms, predominantly physical fatigue, were strongly associated with mortality (unadjusted hazard ratios (HRs) ranged from 1.48 to 2.40). The HRs were attenuated after adjustment for comorbidities and depressive symptoms, although affective and physical fatigue remained independent risk factors for mortality.Demographic, clinical, comorbidity, lifestyle, and psychological factors were associated with fatigue in long-term survivors. Fatigued survivors have a higher mortality risk. Lowering the burden of fatigue by a comprehensive approach might result in better survival.
LB  - PUB:(DE-HGF)16
C6  - pmid:40665014
DO  - DOI:10.1038/s41416-025-03116-z
UR  - https://inrepo02.dkfz.de/record/302855
ER  -