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@ARTICLE{Thong:302855,
      author       = {M. Thong$^*$ and D. Doege$^*$ and L. Koch-Gallenkamp$^*$
                      and H. Bertram and A. Eberle and B. Holleczek and A.
                      Nennecke and A. Waldmann and S. R. Zeissig and R.
                      Pritzkuleit and E. Brähler and H. Brenner$^*$ and V.
                      Arndt$^*$},
      title        = {{F}atigue in long-term cancer survivors: prevalence,
                      associated factors, and mortality. {A} prospective
                      population-based study.},
      journal      = {British journal of cancer},
      volume       = {nn},
      issn         = {0007-0920},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2025-01395},
      pages        = {nn},
      year         = {2025},
      note         = {#EA:C070#EA:C071#LA:C070#LA:C071# / epub},
      abstract     = {We compared fatigue severity in breast, prostate or
                      colorectal cancer survivors 5-16 years post-diagnosis with
                      cancer-free controls, and examined factors associated with
                      fatigue and its association with all-cause mortality in
                      survivors.Participants of the CAncEr Survivorship - A
                      multi-Regional (CAESAR) study completed the Fatigue
                      Assessment Questionnaire (FAQ) between 2009 and 2011. The
                      FAQ assesses affective, cognitive, and physical fatigue, and
                      sleep problems. We derived the odds of fatigue using
                      logistic regression with the 75th percentile of population
                      norms as the cut-off. All-cause mortality (up to end 2021)
                      was estimated using Cox regression models.The sample
                      comprised 6057 survivors, of whom approximately one-third
                      reported affective, cognitive, or physical fatigue.
                      Demographic (age, relationship), clinical (chemotherapy),
                      comorbidity (depression), lifestyle, and psychological
                      factors were associated with higher odds of fatigue symptoms
                      and total fatigue. Fatigue symptoms, predominantly physical
                      fatigue, were strongly associated with mortality (unadjusted
                      hazard ratios (HRs) ranged from 1.48 to 2.40). The HRs were
                      attenuated after adjustment for comorbidities and depressive
                      symptoms, although affective and physical fatigue remained
                      independent risk factors for mortality.Demographic,
                      clinical, comorbidity, lifestyle, and psychological factors
                      were associated with fatigue in long-term survivors.
                      Fatigued survivors have a higher mortality risk. Lowering
                      the burden of fatigue by a comprehensive approach might
                      result in better survival.},
      cin          = {C070 / C071 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C071-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40665014},
      doi          = {10.1038/s41416-025-03116-z},
      url          = {https://inrepo02.dkfz.de/record/302855},
}