TY  - JOUR
AU  - Bütof, Rebecca
AU  - Koi, Lydia
AU  - Löck, Steffen
AU  - Appold, Steffen
AU  - Drewes, Steffen
AU  - Koschel, Dirk
AU  - Kotzerke, Jörg
AU  - Nestle, Ursula
AU  - Adebahr, Sonja
AU  - Zips, Daniel
AU  - Heinzelmann, Frank
AU  - Hehr, Thomas
AU  - Bucher, Dagmar
AU  - Heide, Jürgen
AU  - Belka, Claus
AU  - Manapov, Farkhad
AU  - Wasilewska-Tesluk, Ewa
AU  - Fleckenstein, Jochen
AU  - Krause, Mechthild
AU  - Troost, Esther
AU  - Baumann, Michael
TI  - Accelerated vs. conventionally fractionated postoperative radiotherapy of non-small cell lung cancer-final results of the prematurely terminated PORTAF trial.
JO  - Strahlentherapie und Onkologie
VL  - nn
SN  - 0179-7158
CY  - Heidelberg
PB  - Springer Medizin
M1  - DKFZ-2025-01402
SP  - nn
PY  - 2025
N1  - #LA:E220# / epub
AB  - A prolonged overall treatment time (OTT) has been demonstrated to adversely affect the primary radiation therapy (RT) outcome in various solid tumors, including non-small cell lung cancer (NSCLC). Retrospective data from our group suggested an advantage of shorter OTT also for postoperative RT (PORT) in patients with NSCLC. The PORTAF trial (ClinicalTrials.gov: NCT02189967) was initiated to prospectively test this hypothesis.The multicenter prospective randomized phase II trial in patients with NSCLC investigated whether an accelerated schedule of PORT (7 fractions per week, 2 Gy per fraction, OTT 3.5-4 weeks) improved outcome compared to conventional fractionation (5 fractions per week, 2 Gy per fraction, OTT 5-6 weeks). Target volumes and total radiation doses were stratified in both treatment arms based on individual risk factors. Primary endpoint of the study was locoregional tumor control (LRTC) 36 months after PORT, with 154 patients to be included in each arm.Due to slow accrual and changed indications for PORT, we prematurely closed the trial in 2019. Between 2014 and 2019, eight recruiting centers included 27 evaluable patients. An interim safety analysis performed for the first 21 patients showed nonsignificant differences regarding grade 3 toxicities between the treatment arms, thus not meeting the termination criteria. LRTC was not significantly different between accelerated (73
KW  - Fractionation (Other)
KW  - Non-small-cell lung cancer (Other)
KW  - Overall treatment time (Other)
KW  - Positron-emission tomography (Other)
KW  - Postoperative radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40663146
DO  - DOI:10.1007/s00066-025-02422-y
UR  - https://inrepo02.dkfz.de/record/302862
ER  -