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000302865 1001_ $$aKenkhuis, Marlou-Floor$$b0
000302865 245__ $$aExercise effects on symptoms of depression and anxiety vary by patient, clinical, and intervention characteristics in cancer survivors: Results from pooled analyses of individual participant data of 26 RCTs.
000302865 260__ $$aNew York,NY$$bSpringer$$c2025
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000302865 520__ $$aThis study aimed to investigate whether socio-demographic, clinical, and intervention-related variables moderate the effects of exercise on depression and anxiety symptoms in cancer survivors.Data from 26 RCTs in the POLARIS database were analyzed using a one-step individual participant data (IPD) meta-analytic approach with linear mixed models to assess exercise effects on depression and anxiety symptoms (z-scores). Interaction terms were added to these models to explore moderators. Results are presented as betas (corresponding to Cohen's d effect size).Albeit statistically significant, exercise demonstrated negligible effects on symptoms of depression (β = - 0.11; 95% CI = - 0.16; - 0.06) and anxiety (β = - 0.07; 95% CI = - 0.12; - 0.02) compared to controls. The effects of exercise interventions on depressive symptoms were larger for patients who were not living with a partner (β = - 0.23; 95% CI = - 0.35; - 0.11), had a low/medium education level (β = - 0.14; 95% CI = - 0.21; - 0.07), and who had moderate-to-severe symptoms of depression at baseline (β = - 0.30; 95% CI = - 0.43; - 0.16). Patients with moderate-to-severe symptoms of depression at baseline combined with those not living with a partner or a low/medium education level yielded the largest effect size through exercise (β = - 0.61; 95% CI = - 0.89; - 0.33 and β = - 0.37; 95% CI = - 0.57; - 0.17, respectively). Effects on anxiety symptoms were larger for patients with moderate-to-severe symptoms of anxiety at baseline (β = - 0.17; 95% CI = - 0.32; - 0.01) compared to those with no-to-mild symptoms. Sex, age, cancer type, BMI, and intervention-related variables did not moderate the exercise effects.The findings of this study highlight the heterogeneous response to exercise interventions across various patient subgroups. Patients with moderate-to-severe anxiety or depression, those with a low/medium education, and those not living together with a partner may particularly benefit.
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000302865 650_7 $$2Other$$aAnxiety
000302865 650_7 $$2Other$$aCancer survivors
000302865 650_7 $$2Other$$aDepression
000302865 650_7 $$2Other$$aDistress
000302865 650_7 $$2Other$$aExercise
000302865 650_7 $$2Other$$aModerators
000302865 650_2 $$2MeSH$$aHumans
000302865 650_2 $$2MeSH$$aAnxiety: therapy
000302865 650_2 $$2MeSH$$aAnxiety: etiology
000302865 650_2 $$2MeSH$$aDepression: therapy
000302865 650_2 $$2MeSH$$aDepression: etiology
000302865 650_2 $$2MeSH$$aExercise: psychology
000302865 650_2 $$2MeSH$$aRandomized Controlled Trials as Topic
000302865 650_2 $$2MeSH$$aMale
000302865 650_2 $$2MeSH$$aFemale
000302865 650_2 $$2MeSH$$aNeoplasms: psychology
000302865 650_2 $$2MeSH$$aCancer Survivors: psychology
000302865 650_2 $$2MeSH$$aMiddle Aged
000302865 650_2 $$2MeSH$$aSurvivors: psychology
000302865 650_2 $$2MeSH$$aExercise Therapy: methods
000302865 650_2 $$2MeSH$$aAdult
000302865 7001_ $$aDoorenbos, Meike$$b1
000302865 7001_ $$aMast, Isa H$$b2
000302865 7001_ $$aAaronson, Neil K$$b3
000302865 7001_ $$avan Beurden, Marc$$b4
000302865 7001_ $$aBohus, Martin$$b5
000302865 7001_ $$aCourneya, Kerry S$$b6
000302865 7001_ $$aDaley, Amanda J$$b7
000302865 7001_ $$aGalvão, Daniel A$$b8
000302865 7001_ $$aGoedendorp, Martine M$$b9
000302865 7001_ $$avan Harten, Wim H$$b10
000302865 7001_ $$aHayes, Sandi C$$b11
000302865 7001_ $$aHiensch, Anouk E$$b12
000302865 7001_ $$aIrwin, Melinda L$$b13
000302865 7001_ $$aKersten, Marie José$$b14
000302865 7001_ $$aKnoop, Hans$$b15
000302865 7001_ $$aMay, Anne M$$b16
000302865 7001_ $$aMcConnachie, Alex$$b17
000302865 7001_ $$avan Mechelen, Willem$$b18
000302865 7001_ $$aMutrie, Nanette$$b19
000302865 7001_ $$aNewton, Robert U$$b20
000302865 7001_ $$aNollet, Frans$$b21
000302865 7001_ $$aOldenburg, Hester S$$b22
000302865 7001_ $$0P:(DE-He78)2def8f8594c8f797f5ed4398258c6cac$$aSchmidt, Martina$$b23$$udkfz
000302865 7001_ $$aSchmitz, Kathryn H$$b24
000302865 7001_ $$aSchulz, Karl-Heinz$$b25
000302865 7001_ $$aSonke, Gabe S$$b26
000302865 7001_ $$0P:(DE-He78)a0c2037d9054be26907a05ae520d5756$$aSteindorf, Karen$$b27$$udkfz
000302865 7001_ $$aStuiver, Martijn M$$b28
000302865 7001_ $$aTaaffe, Dennis R$$b29
000302865 7001_ $$aThorsen, Lene$$b30
000302865 7001_ $$aVelthuis, Miranda J$$b31
000302865 7001_ $$aWiskemann, Joachim$$b32
000302865 7001_ $$aMesters, Ilse$$b33
000302865 7001_ $$aUlrich, Cornelia M$$b34
000302865 7001_ $$avan Vulpen, Jonna K$$b35
000302865 7001_ $$aCusters, Jose A E$$b36
000302865 7001_ $$00000-0002-8095-436X$$aBuffart, Laurien M$$b37
000302865 773__ $$0PERI:(DE-600)1463166-0$$a10.1007/s00520-025-09646-9$$gVol. 33, no. 7, p. 647$$n7$$p647$$tSupportive care in cancer$$v33$$x0941-4355$$y2025
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