Home > Publications database > Exercise effects on symptoms of depression and anxiety vary by patient, clinical, and intervention characteristics in cancer survivors: Results from pooled analyses of individual participant data of 26 RCTs. > print

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005     20250718114119.0
024 7 _ |a 10.1007/s00520-025-09646-9
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024 7 _ |a 1433-7339
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037 _ _ |a DKFZ-2025-01405
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Kenkhuis, Marlou-Floor
|b 0
245 _ _ |a Exercise effects on symptoms of depression and anxiety vary by patient, clinical, and intervention characteristics in cancer survivors: Results from pooled analyses of individual participant data of 26 RCTs.
260 _ _ |a New York,NY
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520 _ _ |a This study aimed to investigate whether socio-demographic, clinical, and intervention-related variables moderate the effects of exercise on depression and anxiety symptoms in cancer survivors.Data from 26 RCTs in the POLARIS database were analyzed using a one-step individual participant data (IPD) meta-analytic approach with linear mixed models to assess exercise effects on depression and anxiety symptoms (z-scores). Interaction terms were added to these models to explore moderators. Results are presented as betas (corresponding to Cohen's d effect size).Albeit statistically significant, exercise demonstrated negligible effects on symptoms of depression (β = - 0.11; 95% CI = - 0.16; - 0.06) and anxiety (β = - 0.07; 95% CI = - 0.12; - 0.02) compared to controls. The effects of exercise interventions on depressive symptoms were larger for patients who were not living with a partner (β = - 0.23; 95% CI = - 0.35; - 0.11), had a low/medium education level (β = - 0.14; 95% CI = - 0.21; - 0.07), and who had moderate-to-severe symptoms of depression at baseline (β = - 0.30; 95% CI = - 0.43; - 0.16). Patients with moderate-to-severe symptoms of depression at baseline combined with those not living with a partner or a low/medium education level yielded the largest effect size through exercise (β = - 0.61; 95% CI = - 0.89; - 0.33 and β = - 0.37; 95% CI = - 0.57; - 0.17, respectively). Effects on anxiety symptoms were larger for patients with moderate-to-severe symptoms of anxiety at baseline (β = - 0.17; 95% CI = - 0.32; - 0.01) compared to those with no-to-mild symptoms. Sex, age, cancer type, BMI, and intervention-related variables did not moderate the exercise effects.The findings of this study highlight the heterogeneous response to exercise interventions across various patient subgroups. Patients with moderate-to-severe anxiety or depression, those with a low/medium education, and those not living together with a partner may particularly benefit.
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650 _ 7 |a Anxiety
|2 Other
650 _ 7 |a Cancer survivors
|2 Other
650 _ 7 |a Depression
|2 Other
650 _ 7 |a Distress
|2 Other
650 _ 7 |a Exercise
|2 Other
650 _ 7 |a Moderators
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Anxiety: therapy
|2 MeSH
650 _ 2 |a Anxiety: etiology
|2 MeSH
650 _ 2 |a Depression: therapy
|2 MeSH
650 _ 2 |a Depression: etiology
|2 MeSH
650 _ 2 |a Exercise: psychology
|2 MeSH
650 _ 2 |a Randomized Controlled Trials as Topic
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Neoplasms: psychology
|2 MeSH
650 _ 2 |a Cancer Survivors: psychology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Survivors: psychology
|2 MeSH
650 _ 2 |a Exercise Therapy: methods
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
700 1 _ |a Doorenbos, Meike
|b 1
700 1 _ |a Mast, Isa H
|b 2
700 1 _ |a Aaronson, Neil K
|b 3
700 1 _ |a van Beurden, Marc
|b 4
700 1 _ |a Bohus, Martin
|b 5
700 1 _ |a Courneya, Kerry S
|b 6
700 1 _ |a Daley, Amanda J
|b 7
700 1 _ |a Galvão, Daniel A
|b 8
700 1 _ |a Goedendorp, Martine M
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700 1 _ |a van Harten, Wim H
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700 1 _ |a Hayes, Sandi C
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700 1 _ |a Hiensch, Anouk E
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700 1 _ |a Irwin, Melinda L
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700 1 _ |a Kersten, Marie José
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700 1 _ |a Knoop, Hans
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700 1 _ |a May, Anne M
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700 1 _ |a McConnachie, Alex
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700 1 _ |a van Mechelen, Willem
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700 1 _ |a Mutrie, Nanette
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700 1 _ |a Newton, Robert U
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700 1 _ |a Nollet, Frans
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700 1 _ |a Oldenburg, Hester S
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700 1 _ |a Schmidt, Martina
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700 1 _ |a Schmitz, Kathryn H
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700 1 _ |a Schulz, Karl-Heinz
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700 1 _ |a Sonke, Gabe S
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700 1 _ |a Steindorf, Karen
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700 1 _ |a Stuiver, Martijn M
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700 1 _ |a Taaffe, Dennis R
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700 1 _ |a Thorsen, Lene
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700 1 _ |a Velthuis, Miranda J
|b 31
700 1 _ |a Wiskemann, Joachim
|b 32
700 1 _ |a Mesters, Ilse
|b 33
700 1 _ |a Ulrich, Cornelia M
|b 34
700 1 _ |a van Vulpen, Jonna K
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700 1 _ |a Custers, Jose A E
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700 1 _ |a Buffart, Laurien M
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773 _ _ |a 10.1007/s00520-025-09646-9
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