%0 Journal Article
%A Thews, Oliver
%A Schmid, Thomas
%A Kluttig, Alexander
%A Wienke, Andreas
%A Zinkhan, Melanie
%A Ahrens, Wolfgang
%A Bärnighausen, Till
%A Brenner, Hermann
%A Castell, Stefanie
%A Lange, Berit
%A Lieb, Wolfgang
%A Greiser, Karin-Halina
%A Dörr, Marcus
%A Krist, Lilian
%A Willich, Stefan N
%A Harth, Volker
%A Obi, Nadia
%A Leitzmann, Michael
%A Peters, Annette
%A Schmidt, Börge
%A Schulze, Matthias B
%A Völzke, Henry
%A Nauck, Matthias
%A Zylla, Stephanie
%A Hannemann, Anke
%A Pischon, Tobias
%A Velásquez, Ilais Moreno
%A Girndt, Matthias
%A Grossmann, Claudia
%A Gekle, Michael
%T Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner.
%J BMC medicine
%V 23
%N 1
%@ 1741-7015
%C London
%I BioMed Central
%M DKFZ-2025-01408
%P 356
%D 2025
%X In humans, uric acid is a product of purine metabolism that impacts the vascular system. In addition to effects on arterial vascular tone, associations between serum uric acid concentrations-even in the physiological range-and arterial hypertension and vascular-mediated end-organ damage due to an impact on vascular stiffness have been postulated.Therefore, we aim to investigate a possible cross-sectional association between serum uric acid concentrations in the physiological range and differences in arterial pulse wave velocity (PWV), an indicator of vascular remodeling, with a focus on possible differences between female and male individuals. We analyzed cross-sectional phenotypic and laboratory parameters, including PWV from 70,649 individuals in the population-based German National Cohort (NAKO) in a sex-specific manner. In parallel, we applied a machine learning approach to identify and quantify factors associated with PWV in a hypothesis-free manner.Our analysis uncovered a positive association between serum uric and PWV which was detected even if only individuals with urate values in the physiological range were included (n = 64,095). This correlation was more pronounced in women than in men. In multivariable linear regression models, we observed an association of uric acid (mmol/l) with PWV (m/s) of β = 1.12 (95
%K Humans
%K Vascular Stiffness: physiology
%K Uric Acid: blood
%K Male
%K Female
%K Cross-Sectional Studies
%K Middle Aged
%K Pulse Wave Analysis
%K Adult
%K Sex Factors
%K Aged
%K Germany
%K Female health (Other)
%K Hyperuricemia (Other)
%K Pulse wave velocity (Other)
%K Urate (Other)
%K Vascular damage (Other)
%K Vascular stiffness (Other)
%K Uric Acid (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40597154
%2 pmc:PMC12211650
%R 10.1186/s12916-025-04195-8
%U https://inrepo02.dkfz.de/record/302868