TY  - JOUR
AU  - Thews, Oliver
AU  - Schmid, Thomas
AU  - Kluttig, Alexander
AU  - Wienke, Andreas
AU  - Zinkhan, Melanie
AU  - Ahrens, Wolfgang
AU  - Bärnighausen, Till
AU  - Brenner, Hermann
AU  - Castell, Stefanie
AU  - Lange, Berit
AU  - Lieb, Wolfgang
AU  - Greiser, Karin-Halina
AU  - Dörr, Marcus
AU  - Krist, Lilian
AU  - Willich, Stefan N
AU  - Harth, Volker
AU  - Obi, Nadia
AU  - Leitzmann, Michael
AU  - Peters, Annette
AU  - Schmidt, Börge
AU  - Schulze, Matthias B
AU  - Völzke, Henry
AU  - Nauck, Matthias
AU  - Zylla, Stephanie
AU  - Hannemann, Anke
AU  - Pischon, Tobias
AU  - Velásquez, Ilais Moreno
AU  - Girndt, Matthias
AU  - Grossmann, Claudia
AU  - Gekle, Michael
TI  - Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner.
JO  - BMC medicine
VL  - 23
IS  - 1
SN  - 1741-7015
CY  - London
PB  - BioMed Central
M1  - DKFZ-2025-01408
SP  - 356
PY  - 2025
AB  - In humans, uric acid is a product of purine metabolism that impacts the vascular system. In addition to effects on arterial vascular tone, associations between serum uric acid concentrations-even in the physiological range-and arterial hypertension and vascular-mediated end-organ damage due to an impact on vascular stiffness have been postulated.Therefore, we aim to investigate a possible cross-sectional association between serum uric acid concentrations in the physiological range and differences in arterial pulse wave velocity (PWV), an indicator of vascular remodeling, with a focus on possible differences between female and male individuals. We analyzed cross-sectional phenotypic and laboratory parameters, including PWV from 70,649 individuals in the population-based German National Cohort (NAKO) in a sex-specific manner. In parallel, we applied a machine learning approach to identify and quantify factors associated with PWV in a hypothesis-free manner.Our analysis uncovered a positive association between serum uric and PWV which was detected even if only individuals with urate values in the physiological range were included (n = 64,095). This correlation was more pronounced in women than in men. In multivariable linear regression models, we observed an association of uric acid (mmol/l) with PWV (m/s) of β = 1.12 (95
KW  - Humans
KW  - Vascular Stiffness: physiology
KW  - Uric Acid: blood
KW  - Male
KW  - Female
KW  - Cross-Sectional Studies
KW  - Middle Aged
KW  - Pulse Wave Analysis
KW  - Adult
KW  - Sex Factors
KW  - Aged
KW  - Germany
KW  - Female health (Other)
KW  - Hyperuricemia (Other)
KW  - Pulse wave velocity (Other)
KW  - Urate (Other)
KW  - Vascular damage (Other)
KW  - Vascular stiffness (Other)
KW  - Uric Acid (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40597154
C2  - pmc:PMC12211650
DO  - DOI:10.1186/s12916-025-04195-8
UR  - https://inrepo02.dkfz.de/record/302868
ER  -