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@ARTICLE{Krber:302875,
      author       = {V. Körber$^*$ and N. A. Jakobsen and N. Ansari-Pour and R.
                      Moore and N. Claudino$^*$ and M. Metzner and E.
                      Thielecke$^*$ and F. Esau$^*$ and B. Usukhbayar and M. A.
                      Salazar and S. Newman and B. J. L. Kendrick and A. H. Taylor
                      and R. Afinowi-Luitz and R. Gundle and B. Watkins and K.
                      Wheway and D. Beazley and S. G. Dakin and A. Palmer and A.
                      J. Carr and P. Vyas and T. Höfer$^*$},
      title        = {{D}etecting and quantifying clonal selection in somatic
                      stem cells.},
      journal      = {Nature genetics},
      volume       = {57},
      number       = {7},
      issn         = {1061-4036},
      address      = {London},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2025-01415},
      pages        = {1718-1729},
      year         = {2025},
      note         = {#EA:B086#LA:B086# / 2025 Jul;57(7):1718-1729},
      abstract     = {As DNA variants accumulate in somatic stem cells, become
                      selected or evolve neutrally, they may ultimately alter
                      tissue function. When, and how, selection occurs in
                      homeostatic tissues is incompletely understood. Here, we
                      introduce SCIFER, a scalable method that identifies
                      selection in an individual tissue, without requiring
                      knowledge of the driver event. SCIFER also infers
                      self-renewal and mutation dynamics of the tissue's stem
                      cells, and the size and age of selected clones. Probing bulk
                      whole-genome sequencing data of nonmalignant human bone
                      marrow and brain, we detected pervasive selection in both
                      tissues. Selected clones in hematopoiesis, with or without
                      known drivers, were initiated uniformly across life. In the
                      brain, we found pre-malignant clones with glioma-initiating
                      mutations and clones without known drivers. In contrast to
                      hematopoiesis, selected clones in the brain originated
                      preferentially from childhood to young adulthood. SCIFER is
                      broadly applicable to renewing somatic tissues to detect and
                      quantify selection.},
      cin          = {B086},
      ddc          = {570},
      cid          = {I:(DE-He78)B086-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40610627},
      doi          = {10.1038/s41588-025-02217-y},
      url          = {https://inrepo02.dkfz.de/record/302875},
}