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@ARTICLE{Yang:302884,
      author       = {J. Yang and Q. Zhong$^*$ and L. Peng$^*$},
      title        = {{A}ssociation between the seroprevalence of infectious
                      pathogens and depression in {U}.{S}. adults.},
      journal      = {Psychiatry research / Neuroimaging},
      volume       = {351},
      issn         = {0925-4927},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-01424},
      pages        = {116627},
      year         = {2025},
      note         = {#LA:C070#},
      abstract     = {There is a paucity of knowledge concerning the relationship
                      between exposure to various pathogens and depression in
                      adults residing in the United States. The objective of the
                      study was to examine the prevalence and severity of
                      depression in populations at risk of viral infections and to
                      investigate the potential association between these two
                      factors.This study was derived from the National Health and
                      Nutrition Examination Survey (NHANES), which included 39,749
                      participants aged 20 years or older between 2005 and 2018.
                      The Patient Health Questionnaire-9 (PHQ-9) was employed to
                      assess the presence and severity of depressive symptoms.
                      Multivariable logistic regression analyses were conducted to
                      evaluate the odds ratios and associations between viral
                      seropositivity and depression.Significant associations were
                      observed between seropositivity for hepatitis A virus (HAV),
                      hepatitis C virus (HCV), human immunodeficiency virus (HIV),
                      human papillomavirus (HPV) types 6, 11, 16, and 18, and
                      herpes simplex virus (HSV) type 2 and an increased risk of
                      depression (all p-values < 0.05). No significant
                      associations were observed for hepatitis B virus (HBV),
                      hepatitis D virus (HDV), hepatitis E virus (HEV), or HSV
                      type 1.Seropositivity for HPV types 6, 11, 16, and 18, HAV,
                      HCV, HIV, and HSV-2 was significantly associated with
                      depression in a representative sample of U.S. adults.},
      keywords     = {Depression (Other) / Infectious pathogen (Other) / Odds
                      ratio (Other)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40633509},
      doi          = {10.1016/j.psychres.2025.116627},
      url          = {https://inrepo02.dkfz.de/record/302884},
}