%0 Journal Article
%A Herz, Andreas
%A Guberina, Maja
%A Pöttgen, Christoph
%A Gauler, Thomas
%A Ton, That Truong Mike
%A Fischedick, Gerrit
%A Kiwitt, Lars Oliver
%A Lübcke, Wolfgang
%A Hoffmann, Christian
%A Schuler, Martin
%A Metzenmacher, Martin
%A Schaarschmidt, Benedikt M
%A Bos, Denise
%A Opitz, Marcel
%A Hautzel, Hubertus
%A Darwiche, Kaid
%A Bölükbas, Servet
%A Grapatsas, Konstantinos
%A Jendrossek, Verena
%A Gockeln, Lena
%A Wirsdörfer, Florian
%A Hetzel, Mario
%A Mladenov, Emil
%A Stuschke, Martin
%A Guberina, Nika
%T The effect of durvalumab consolidation after definitive radiochemotherapy for non-operable stage III non-small cell lung cancer on the dose effect relation for therapy related pulmonary infiltrates as a risk factor for pneumonitis.
%J Translational Lung Cancer Research
%V 14
%N 6
%@ 2218-6751
%C [Erscheinungsort nicht ermittelbar]
%I [Verlag nicht ermittelbar]
%M DKFZ-2025-01434
%P 2074 - 2088
%D 2025
%X Consolidation therapy with the anti-programmed death-ligand 1 (PD-L1) antibody durvalumab, or other immune checkpoint inhibitors, has been associated with improved progression-free and overall survival in patients with stage III non-small cell lung cancer (NSCLC) as demonstrated in randomized clinical trials. The purpose of the present study is to evaluate the dose-response relationship for partial lung infiltrate volumes per dose bin after definitive radiochemotherapy as a sensitive end point to detect a durvalumab effect on the lung parenchyma in patients with subclinical or grade ≤2 pneumonitis.Consecutive patients from a prospective registry with inoperable NSCLC stage III who developed no or pneumonitis grade ≤2 after definitive radiochemotherapy with or without durvalumab consolidation were included. Pulmonary infiltrates outside the planning target volumes were contoured in the follow-up computed tomography (CT) at the time of maximum infiltrate expression. Partial lung infiltrate volumes per dose bin were determined over the entire dose range. A mixed random and fixed effect model was used to fit dose response curves stepwise in dose bins of 5 Gy. The Akaike information criterion (AIC) was used for model comparison.Sixty patients with and 44 without durvalumab consolidation were analysed. The step model showed a significant dose response relationship for the pulmonary infiltrates (P<0.001, F-test) that was modified by the durvalumab effect (P<0.001, F-test). There was a significant dependence of the durvalumab effect on radiation dose (P=0.003). The durvalumab effect increased with dose from 0
%K Pneumonitis (Other)
%K durvalumab consolidation (Other)
%K immunotherapy (Other)
%K lung cancer (Other)
%K radiation therapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40673077
%2 pmc:PMC12261351
%R 10.21037/tlcr-2024-1284
%U https://inrepo02.dkfz.de/record/302987