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000302991 1001_ $$aBeumer, Niklas$$b0
000302991 245__ $$aDNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.
000302991 260__ $$aLondon$$bSpringer Nature Limited$$c2025
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000302991 520__ $$aCD4+ regulatory T (Treg) cells in tissues play crucial immunoregulatory and regenerative roles. Despite their importance, the epigenetics and differentiation of human tissue Treg cells are incompletely understood. Here, we performed genome-wide DNA methylation analysis of human Treg cells from skin and blood and integrated these data into a multiomic framework, including chromatin accessibility and gene expression. This analysis identified programs that governed the tissue adaptation of skin Treg cells. We found that subfamilies of transposable elements represented a major constituent of the hypomethylated landscape in tissue Treg cells. Based on T cell antigen receptor sequence and DNA hypomethylation homologies, our data indicate that blood CCR8+ Treg cells contain recirculating human skin Treg cells. Conversely, differences in chromatin accessibility and gene expression suggest a certain reversal of the tissue adaptation program during recirculation. Our findings provide insights into the biology of human tissue Treg cells, which may help harness these cells for therapeutic purposes.
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000302991 7001_ $$00000-0003-4920-551X$$aImbusch, Charles D$$b1$$eFirst author
000302991 7001_ $$00000-0003-4294-8767$$aKaufmann, Tamara$$b2
000302991 7001_ $$aSchmidleithner, Lisa$$b3
000302991 7001_ $$aGütter, Kathrin$$b4
000302991 7001_ $$aStüve, Philipp$$b5
000302991 7001_ $$00009-0000-4242-8505$$aMarchel, Harriet$$b6
000302991 7001_ $$0P:(DE-He78)ff4024f7bc236e7897d9c18ee19c451f$$aWeichenhan, Dieter$$b7$$udkfz
000302991 7001_ $$0P:(DE-He78)cfd12c2b002e4edb674103723a470712$$aBähr, Marion$$b8$$udkfz
000302991 7001_ $$aRuhland, Brigitte$$b9
000302991 7001_ $$00000-0003-3252-7758$$aMarini, Federico$$b10
000302991 7001_ $$aSanderink, Lieke$$b11
000302991 7001_ $$aRitter, Uwe$$b12
000302991 7001_ $$0P:(DE-He78)de4915d76b207d077967848783f8d2ba$$aSimon, Malte$$b13
000302991 7001_ $$aBraband, Kathrin Luise$$b14
000302991 7001_ $$aVoss, Morten Michael$$b15
000302991 7001_ $$aHelbich, Sara Salome$$b16
000302991 7001_ $$aMihoc, Delia Mihaela$$b17
000302991 7001_ $$0P:(DE-He78)2f34b89d62d5e5c651aa1e683844b092$$aHotz-Wagenblatt, Agnes$$b18
000302991 7001_ $$aNassabi, Hadrian$$b19
000302991 7001_ $$aEigenberger, Andreas$$b20
000302991 7001_ $$aPrantl, Lukas$$b21
000302991 7001_ $$aGebhard, Claudia$$b22
000302991 7001_ $$aRehli, Michael$$b23
000302991 7001_ $$00000-0003-1183-1099$$aStrieder, Nicholas$$b24
000302991 7001_ $$aSingh, Kartikeya$$b25
000302991 7001_ $$aSchmidl, Christian$$b26
000302991 7001_ $$0P:(DE-He78)4301875630bc997edf491c694ae1f8a9$$aPlass, Christoph$$b27$$udkfz
000302991 7001_ $$00000-0001-8071-1379$$aHuehn, Jochen$$b28
000302991 7001_ $$aHehlgans, Thomas$$b29
000302991 7001_ $$00000-0003-4727-2540$$aPolansky, Julia K$$b30
000302991 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b31$$eLast author$$udkfz
000302991 7001_ $$aDelacher, Michael$$b32
000302991 7001_ $$aFeuerer, Markus$$b33
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