TY  - JOUR
AU  - Beumer, Niklas
AU  - Imbusch, Charles D
AU  - Kaufmann, Tamara
AU  - Schmidleithner, Lisa
AU  - Gütter, Kathrin
AU  - Stüve, Philipp
AU  - Marchel, Harriet
AU  - Weichenhan, Dieter
AU  - Bähr, Marion
AU  - Ruhland, Brigitte
AU  - Marini, Federico
AU  - Sanderink, Lieke
AU  - Ritter, Uwe
AU  - Simon, Malte
AU  - Braband, Kathrin Luise
AU  - Voss, Morten Michael
AU  - Helbich, Sara Salome
AU  - Mihoc, Delia Mihaela
AU  - Hotz-Wagenblatt, Agnes
AU  - Nassabi, Hadrian
AU  - Eigenberger, Andreas
AU  - Prantl, Lukas
AU  - Gebhard, Claudia
AU  - Rehli, Michael
AU  - Strieder, Nicholas
AU  - Singh, Kartikeya
AU  - Schmidl, Christian
AU  - Plass, Christoph
AU  - Huehn, Jochen
AU  - Hehlgans, Thomas
AU  - Polansky, Julia K
AU  - Brors, Benedikt
AU  - Delacher, Michael
AU  - Feuerer, Markus
TI  - DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.
JO  - Nature immunology
VL  - 26
IS  - 8
SN  - 1529-2908
CY  - London
PB  - Springer Nature Limited
M1  - DKFZ-2025-01438
SP  - 1315-1328
PY  - 2025
N1  - #EA:B330#LA:B330# / 2025 Aug;26(8):1315-1328
AB  - CD4+ regulatory T (Treg) cells in tissues play crucial immunoregulatory and regenerative roles. Despite their importance, the epigenetics and differentiation of human tissue Treg cells are incompletely understood. Here, we performed genome-wide DNA methylation analysis of human Treg cells from skin and blood and integrated these data into a multiomic framework, including chromatin accessibility and gene expression. This analysis identified programs that governed the tissue adaptation of skin Treg cells. We found that subfamilies of transposable elements represented a major constituent of the hypomethylated landscape in tissue Treg cells. Based on T cell antigen receptor sequence and DNA hypomethylation homologies, our data indicate that blood CCR8+ Treg cells contain recirculating human skin Treg cells. Conversely, differences in chromatin accessibility and gene expression suggest a certain reversal of the tissue adaptation program during recirculation. Our findings provide insights into the biology of human tissue Treg cells, which may help harness these cells for therapeutic purposes.
LB  - PUB:(DE-HGF)16
C6  - pmid:40670618
DO  - DOI:10.1038/s41590-025-02210-x
UR  - https://inrepo02.dkfz.de/record/302991
ER  -