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@ARTICLE{Beumer:302991,
      author       = {N. Beumer and C. D. Imbusch$^*$ and T. Kaufmann and L.
                      Schmidleithner and K. Gütter and P. Stüve and H. Marchel
                      and D. Weichenhan$^*$ and M. Bähr$^*$ and B. Ruhland and F.
                      Marini and L. Sanderink and U. Ritter and M. Simon$^*$ and
                      K. L. Braband and M. M. Voss and S. S. Helbich and D. M.
                      Mihoc and A. Hotz-Wagenblatt$^*$ and H. Nassabi and A.
                      Eigenberger and L. Prantl and C. Gebhard and M. Rehli and N.
                      Strieder and K. Singh and C. Schmidl and C. Plass$^*$ and J.
                      Huehn and T. Hehlgans and J. K. Polansky and B. Brors$^*$
                      and M. Delacher and M. Feuerer},
      title        = {{DNA} hypomethylation traits define human regulatory {T}
                      cells in cutaneous tissue and identify their blood
                      recirculating counterparts.},
      journal      = {Nature immunology},
      volume       = {26},
      number       = {8},
      issn         = {1529-2908},
      address      = {London},
      publisher    = {Springer Nature Limited},
      reportid     = {DKFZ-2025-01438},
      pages        = {1315-1328},
      year         = {2025},
      note         = {#EA:B330#LA:B330# / 2025 Aug;26(8):1315-1328},
      abstract     = {CD4+ regulatory T (Treg) cells in tissues play crucial
                      immunoregulatory and regenerative roles. Despite their
                      importance, the epigenetics and differentiation of human
                      tissue Treg cells are incompletely understood. Here, we
                      performed genome-wide DNA methylation analysis of human Treg
                      cells from skin and blood and integrated these data into a
                      multiomic framework, including chromatin accessibility and
                      gene expression. This analysis identified programs that
                      governed the tissue adaptation of skin Treg cells. We found
                      that subfamilies of transposable elements represented a
                      major constituent of the hypomethylated landscape in tissue
                      Treg cells. Based on T cell antigen receptor sequence and
                      DNA hypomethylation homologies, our data indicate that blood
                      CCR8+ Treg cells contain recirculating human skin Treg
                      cells. Conversely, differences in chromatin accessibility
                      and gene expression suggest a certain reversal of the tissue
                      adaptation program during recirculation. Our findings
                      provide insights into the biology of human tissue Treg
                      cells, which may help harness these cells for therapeutic
                      purposes.},
      cin          = {B370 / W610 / HD01 / B330},
      ddc          = {610},
      cid          = {I:(DE-He78)B370-20160331 / I:(DE-He78)W610-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B330-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40670618},
      doi          = {10.1038/s41590-025-02210-x},
      url          = {https://inrepo02.dkfz.de/record/302991},
}