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| 001 | 302991 | ||
| 005 | 20250731103553.0 | ||
| 024 | 7 | _ | |a 10.1038/s41590-025-02210-x |2 doi |
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| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Beumer, Niklas |b 0 |
| 245 | _ | _ | |a DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts. |
| 260 | _ | _ | |a London |c 2025 |b Springer Nature Limited |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1753950917_19398 |2 PUB:(DE-HGF) |
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| 500 | _ | _ | |a #EA:B330#LA:B330# / 2025 Aug;26(8):1315-1328 |
| 520 | _ | _ | |a CD4+ regulatory T (Treg) cells in tissues play crucial immunoregulatory and regenerative roles. Despite their importance, the epigenetics and differentiation of human tissue Treg cells are incompletely understood. Here, we performed genome-wide DNA methylation analysis of human Treg cells from skin and blood and integrated these data into a multiomic framework, including chromatin accessibility and gene expression. This analysis identified programs that governed the tissue adaptation of skin Treg cells. We found that subfamilies of transposable elements represented a major constituent of the hypomethylated landscape in tissue Treg cells. Based on T cell antigen receptor sequence and DNA hypomethylation homologies, our data indicate that blood CCR8+ Treg cells contain recirculating human skin Treg cells. Conversely, differences in chromatin accessibility and gene expression suggest a certain reversal of the tissue adaptation program during recirculation. Our findings provide insights into the biology of human tissue Treg cells, which may help harness these cells for therapeutic purposes. |
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| 700 | 1 | _ | |a Imbusch, Charles D |0 0000-0003-4920-551X |b 1 |e First author |
| 700 | 1 | _ | |a Kaufmann, Tamara |0 0000-0003-4294-8767 |b 2 |
| 700 | 1 | _ | |a Schmidleithner, Lisa |b 3 |
| 700 | 1 | _ | |a Gütter, Kathrin |b 4 |
| 700 | 1 | _ | |a Stüve, Philipp |b 5 |
| 700 | 1 | _ | |a Marchel, Harriet |0 0009-0000-4242-8505 |b 6 |
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| 700 | 1 | _ | |a Ruhland, Brigitte |b 9 |
| 700 | 1 | _ | |a Marini, Federico |0 0000-0003-3252-7758 |b 10 |
| 700 | 1 | _ | |a Sanderink, Lieke |b 11 |
| 700 | 1 | _ | |a Ritter, Uwe |b 12 |
| 700 | 1 | _ | |a Simon, Malte |0 P:(DE-He78)de4915d76b207d077967848783f8d2ba |b 13 |
| 700 | 1 | _ | |a Braband, Kathrin Luise |b 14 |
| 700 | 1 | _ | |a Voss, Morten Michael |b 15 |
| 700 | 1 | _ | |a Helbich, Sara Salome |b 16 |
| 700 | 1 | _ | |a Mihoc, Delia Mihaela |b 17 |
| 700 | 1 | _ | |a Hotz-Wagenblatt, Agnes |0 P:(DE-He78)2f34b89d62d5e5c651aa1e683844b092 |b 18 |
| 700 | 1 | _ | |a Nassabi, Hadrian |b 19 |
| 700 | 1 | _ | |a Eigenberger, Andreas |b 20 |
| 700 | 1 | _ | |a Prantl, Lukas |b 21 |
| 700 | 1 | _ | |a Gebhard, Claudia |b 22 |
| 700 | 1 | _ | |a Rehli, Michael |b 23 |
| 700 | 1 | _ | |a Strieder, Nicholas |0 0000-0003-1183-1099 |b 24 |
| 700 | 1 | _ | |a Singh, Kartikeya |b 25 |
| 700 | 1 | _ | |a Schmidl, Christian |b 26 |
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| 700 | 1 | _ | |a Huehn, Jochen |0 0000-0001-8071-1379 |b 28 |
| 700 | 1 | _ | |a Hehlgans, Thomas |b 29 |
| 700 | 1 | _ | |a Polansky, Julia K |0 0000-0003-4727-2540 |b 30 |
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| 700 | 1 | _ | |a Delacher, Michael |b 32 |
| 700 | 1 | _ | |a Feuerer, Markus |b 33 |
| 773 | _ | _ | |a 10.1038/s41590-025-02210-x |0 PERI:(DE-600)2026412-4 |n 8 |p 1315-1328 |t Nature immunology |v 26 |y 2025 |x 1529-2908 |
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