TY  - JOUR
AU  - Langer, Susan
AU  - Medenwald, Daniel
AU  - Vordermark, Dirk
AU  - Schuette, Wolfgang
AU  - Deppermann, Karl-Matthias
AU  - Nothacker, Monika
AU  - Eggeling, Stephan
AU  - Efremov, Ljupcho
TI  - Therapeutic modalities for superior sulcus tumor (Pancoast) tumor - A systematic review.
JO  - Lung cancer
VL  - 206
SN  - 0169-5002
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2025-01461
SP  - 108640
PY  - 2025
N1  - #LA:C020#
AB  - Superior sulcus tumors (SST) are usually treated with multimodal therapy, mainly trimodal therapy encompassing radiochemotherapy (CRT) followed by surgery. However, high-level evidence from randomized trials remains limited. We conducted a systematic review to assess the evidence of treatment strategies considering adverse events and oncologic outcomes.We systematically searched MEDLINE, CINAHL, EMBASE, Web of Science, CENTRAL, grey literature databases, and clinical trial registries. We included prospective and retrospective studies published between 1990 and 2024 with mono-, bi- or trimodal treatment reporting outcomes such as overall survival (OS), progression-free survival (PFS), resection rates, postoperative mortality/morbidity, and adverse events. Studies required histologically confirmed SST and a minimum of 30 patients.Thirty-five studies were included (28 retrospective, 7 prospective), with follow-up ranging from 10 to 107 months. Most studies originated from Europe (n = 16) and North America (n = 14). Sample sizes ranged from 30 to 2910 patients, predominantly male and aged in the late 50s to early 60s. Induction CRT protocols varied widely. R0 resection rates were reported in 33 studies, and trimodal therapy outcomes in 12. Hematotoxicity and esophagitis were the most common adverse events. Five-year OS rates varied between 11.8 
KW  - Lung cancer (Other)
KW  - NSCLC (Other)
KW  - Radiochemotherapy (Other)
KW  - Sulcus superior tumor (Other)
KW  - Systematic review (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40651130
DO  - DOI:10.1016/j.lungcan.2025.108640
UR  - https://inrepo02.dkfz.de/record/303014
ER  -