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@ARTICLE{Dietz:303016,
      author       = {A. Dietz and K. Taylor and O. Bayer and S. Singer and M.
                      Follmann and M. Nothacker and T. Langer and P. Klussmann and
                      S. Lang and T. Hoffmann and G. Maschmeyer and S. Wiegand and
                      M. Fuchs and W. Weichert and J. Hess$^*$ and O.
                      Guntinas-Lichius and T. Waterboer$^*$ and M. Lell and J.
                      Büntzel and P. Balermpas and K. Schmidt and M. Steingräber
                      and G. Klautke and H. Hellmund and G. Kissinger and P.
                      Brossart and I. Maatouk and B. Lethaus and J. Raguse and K.
                      Zöphel and K. Lippach and F. Sterr and H. Christiansen and
                      C. Duncker and A. Keilmann and H. Cici and J. Yzer and A.
                      Relic and K. Paradies and W. Budach},
      title        = {{E}vidence-based guideline diagnosis, treatment, prevention
                      and aftercare of oropharyngeal and hypopharyngeal carcinoma.
                      = {GMS} {G}er {M}ed {S}ci},
      journal      = {GMS german medical science},
      volume       = {23},
      issn         = {1612-3174},
      address      = {Berlin},
      publisher    = {German Medical Science (GMS) gGmbH},
      reportid     = {DKFZ-2025-01463},
      pages        = {Doc03},
      year         = {2025},
      note         = {2025 Jun 24:23:Doc03},
      abstract     = {The guideline is being drawn up as a joint guideline for
                      oropharyngeal and hypopharyngeal carcinoma. Oropharyngeal
                      carcinoma in particular has experienced the greatest
                      increase in incidence among all head and neck carcinomas in
                      the last 20 years and is now the sixth most common cancer in
                      men in Germany. Together with hypopharyngeal carcinoma,
                      these tumors are currently the most common cancer entity in
                      the head and neck region. Due to the association with human
                      papillomavirus type 16 (HPV16), we now distinguish two
                      groups of oropharyngeal carcinomas in Germany:
                      HPV16-positive (approx. $35\%)$ and HPV-negative (approx.
                      $65\%).$ A HPV16 association with hypopharyngeal carcinoma
                      has not been described. The therapy covers the entire
                      spectrum of head and neck surgery, including diversified
                      reconstructive procedures, transoral and external
                      approaches, the options for primary and adjuvant
                      radiotherapy (possibly in combination with chemotherapy) and
                      the current recommendations for drug-based tumor therapy,
                      which range from classic chemotherapy to immuno-oncology. In
                      addition, measures for early detection and prevention are
                      carried out, with particular consideration of the
                      HPV16-associated genesis of oropharyngeal carcinoma, as well
                      as adequate rehabilitation after the primary treatment of
                      oropharyngeal and hypopharyngeal carcinomas. Finally, the
                      treatment options for recurrences or distant metastases that
                      cannot be cured in the further course of the disease are
                      shown and classified.},
      subtyp        = {Review Article},
      keywords     = {Humans / Male / Aftercare: standards / Combined Modality
                      Therapy / Evidence-Based Medicine / Germany / Human
                      papillomavirus 16 / Hypopharyngeal Neoplasms: therapy /
                      Hypopharyngeal Neoplasms: diagnosis / Hypopharyngeal
                      Neoplasms: prevention $\&$ control / Hypopharyngeal
                      Neoplasms: virology / Oropharyngeal Neoplasms: therapy /
                      Oropharyngeal Neoplasms: diagnosis / Oropharyngeal
                      Neoplasms: prevention $\&$ control / Oropharyngeal
                      Neoplasms: virology / Papillomavirus Infections: diagnosis /
                      Papillomavirus Infections: therapy / HPV16 (Other) / head
                      and neck cancer (Other) / hypopharynx carcinoma (Other) /
                      oropahyrnx carcinoma (Other) / p16 (Other)},
      cin          = {E220 / D320},
      ddc          = {310},
      cid          = {I:(DE-He78)E220-20160331 / I:(DE-He78)D320-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40655928},
      pmc          = {pmc:PMC12247573},
      doi          = {10.3205/000339},
      url          = {https://inrepo02.dkfz.de/record/303016},
}