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@ARTICLE{Ernst:303021,
      author       = {J. Ernst and S. Reinsch and H.-J. Mentzel and T. Milde$^*$
                      and B. Gruhn},
      title        = {{S}uccessful treatment with mesenchymal stromal
                      cells-{F}rankfurt am {M}ain in a pediatric patient with
                      steroid-refractory and ruxolitinib-refractory acute
                      gastrointestinal graft-versus-host disease.},
      journal      = {Annals of hematology},
      volume       = {nn},
      issn         = {0939-5555},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {DKFZ-2025-01468},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Acute graft-versus-host disease (aGVHD) as complication
                      after allogeneic hematopoetic stem cell transplantation
                      (allo-HSCT) occurs in up to $70\%$ of patients. The survival
                      prognosis depends on the severity of GVHD and response to
                      first-line therapy. In patients who are refractory to both,
                      steroids and ruxolitinib, an unmet medical need exists,
                      especially in severe gastrointestinal forms of aGVHD. We
                      report the case of a 12-year-old male patient who developed
                      severe gastrointestinal aGVHD after allo-HSCT for the
                      treatment of high-risk acute myeloid leukemia. The grade IV
                      aGVHD of the intestine showed no improvement under triple
                      immunosuppression with corticosteroids, cyclosporine A and
                      ruxolitinib. After receiving four weekly infusions of human
                      allogeneic mesenchymal stromal cells DRK-BaWü-He-FFM
                      (MSC-FFM), intestinal inflammation finally improved, as
                      reflected by ameliorated symptoms, normalized intestinal
                      wall thickness (ultrasonography) and decreasing calprotectin
                      levels. Intestinal mucosal healing was further supported by
                      a strict, formula-based modular diet. The present case
                      supports efficacy and safety of MSC-FFM in combination with
                      modular nutrition in complicated courses of aGVHD of the
                      intestine refractory to multiple lines of therapy and
                      introduces intestinal wall thickness and calprotectin levels
                      as valuable markers of disease activity.},
      keywords     = {Acute graft-versus-host disease (Other) / Calprotectin
                      (Other) / Hematopoietic stem cell transplantation (Other) /
                      Intestinal wall thickness (Other) / MSC-FFM (Other) /
                      Mesenchymal stromal cells (Other)},
      cin          = {B310},
      ddc          = {610},
      cid          = {I:(DE-He78)B310-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40663111},
      doi          = {10.1007/s00277-025-06491-y},
      url          = {https://inrepo02.dkfz.de/record/303021},
}