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@ARTICLE{Diexer:303023,
      author       = {S. Diexer and J. Frost and P. Ahnert and T. W.
                      Baernighausen and H. Brenner$^*$ and J. Fricke and S.
                      Gabrysch and K.-H. Greiser$^*$ and V. Harth and J.-K. Heise
                      and R. Kaaks$^*$ and A. Karch and T. Keil and B. Klee and C.
                      J. Klett-Tammen and L. Krist and B. M. J. Lampl and M. F.
                      Leitzmann and W. Lieb and C. Meinke-Franze and K. B. Michels
                      and I. M. Velásquez and N. Obi and A. Peters and L. R.
                      Pfrommer and T. Pischon and O. Purschke and N. Rübsamen and
                      T. Schikowski and B. Schmidt and S. Thierry and H. Völzke
                      and M. N. Wright and H. Zeeb and R. Mikolajczyk},
      title        = {{C}ross-sectional study of health impairment related to
                      post {COVID}-19 condition among participants of a large
                      population-based cohort in {G}ermany.},
      journal      = {Scientific reports},
      volume       = {15},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-01470},
      pages        = {25830},
      year         = {2025},
      abstract     = {Post COVID-19 condition (PCC) is a substantial burden for
                      patients, society, and the healthcare system. Participants
                      of the German National Cohort (NAKO) were asked in an online
                      survey about their self-perceived health, symptoms related
                      to PCC, and infection status. PCC was defined as reporting
                      symptoms for the time window 4-12 months after infection. Of
                      110,375 respondents $(73\%$ response), 86,833 were included
                      in this analysis. Of these, 44,451 $(51\%)$ did not report a
                      SARS-CoV-2 infection (no infection), 26,726 $(31\%)$
                      reported an infection but no symptoms 4-12 months after
                      infection (infection/no PCC), and 15,656 $(18\%)$ reported
                      an infection and symptoms (PCC). The median number of
                      current symptoms at the time of the survey was two for the
                      'no infection' and the 'infection/no PCC' group, and five
                      for the 'PCC' group. Participants with PCC had a
                      substantially higher probability of having worse
                      self-perceived health (OR 1.84, $95\%$ CI [1.75; 1.93]
                      compared to the 'no infection' group, adjusting for sex,
                      age, education and chronic diseases with elevated risk for
                      developing PCC. After adjusting for the number of current
                      symptoms related to PCC, this difference disappeared,
                      suggesting that the symptoms collected explain the
                      impairment of self-perceived health in the PCC group.},
      keywords     = {Humans / COVID-19: epidemiology / COVID-19: complications /
                      Germany: epidemiology / Female / Male / Middle Aged /
                      Cross-Sectional Studies / Adult / Aged / SARS-CoV-2:
                      isolation $\&$ purification / Surveys and Questionnaires /
                      Health Status / Cohort Studies / Post-Acute COVID-19
                      Syndrome},
      cin          = {C020 / C070},
      ddc          = {600},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40670423},
      pmc          = {pmc:PMC12267414},
      doi          = {10.1038/s41598-025-07894-7},
      url          = {https://inrepo02.dkfz.de/record/303023},
}