%0 Journal Article
%A Egen, Luisa
%A Hommel, Moritz
%A Haney, Caelan Max
%A Özdemir, Berkin
%A Knoedler, Samuel
%A Sellner, Jan
%A Seidlitz, Silvia
%A Dietrich, Maximilian
%A Salg, Gabriel Alexander
%A Nickel, Felix
%A Maier-Hein, Lena
%A Michel, Maurice Stephan
%A Studier-Fischer, Alexander
%A Kowalewski, Karl-Friedrich
%T Hyperspectral Imaging Accurately Detects Renal Malperfusion Due to High Intrarenal Pressure.
%J European urology open science
%V 78
%@ 2666-1691
%C [Amsterdam]
%I Elsevier ScienceDirect
%M DKFZ-2025-01487
%P 16 - 27
%D 2025
%Z #EA:E140#LA:E140#
%X High intrarenal pressure (IRP) is a significant concern in both endoscopic procedures and acute hydronephrosis, and may cause renal parenchymal damage, forniceal rupture, and long-term impaired renal function. Its pathomechanism and effect on renal perfusion patterns remain undetermined. This study investigates the impact of elevated IRP on renal perfusion and oxygen saturation (StO2) using hyperspectral imaging (HSI).In vivo experiments were conducted on porcine models establishing hydronephrosis on specific IRP levels (30, 50, 70, and 90 mmHg) by pressure-controlled infusion of crystalloid solution into the ureter after distal ureteral clamping. HSI data were recorded at baseline, during IRP application, and after release to measure hydronephrosis-induced changes in reflectance and perfusion in a total of 501 recordings. The results were compared with spectral patterns of renal malperfusion states from previous internal studies. In total, data of 73 pigs and 1744 HSI recordings were included.Elevated IRP significantly affected renal perfusion and oxygenation. StO2 decreased from 70.3
%K Animal study (Other)
%K Hydronephrosis (Other)
%K Hyperspectral imaging (Other)
%K Intrarenal pressure (Other)
%K Porcine model (Other)
%K Urology (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40688377
%2 pmc:PMC12274906
%R 10.1016/j.euros.2025.06.007
%U https://inrepo02.dkfz.de/record/303040