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@ARTICLE{Lolansen:303082,
      author       = {S. D. Lolansen and E. O. Révész and S. N. Andreassen and
                      M. Trapp$^*$ and C. Salio and M. Sassoé-Pognetto and J. V.
                      Andersen and E. W. Westi and T. L. Toft-Bertelsen and J. H.
                      Wardman and A. M. Lundby and F. Dela and A. Patrizi$^*$ and
                      B. I. Aldana and N. MacAulay},
      title        = {{C}horoid plexus-mediated {CSF} secretion remains stable in
                      aging rats via high and age-resistant metabolic activity.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2025-01507},
      pages        = {6778},
      year         = {2025},
      note         = {Schaller Research Group, German Cancer Research Center
                      (DKFZ), Heidelberg, Germany.},
      abstract     = {Our brain is bathed in cerebrospinal fluid (CSF) that is
                      produced by the choroid plexus. CSF serves as a dispersion
                      route for hormones and nutrients, and a conduit for waste
                      clearance. Age-dependent reduction in the CSF secretion rate
                      could influence cerebral waste clearance and thereby promote
                      cognitive deficits in the elderly. Here, we resolve
                      age-dependent modulation of CSF dynamics and choroid plexus
                      function by complementary in vivo determinations of
                      intracranial pressure (ICP) and CSF secretion/absorption
                      rates, combined with transcriptomic, morphological, and
                      metabolic analysis of choroid plexus in aging male rats. ICP
                      and CSF secretion rate and absorption capacity remain stable
                      with age, and the choroid plexus retains its morphology,
                      structural integrity, gene expression, and high metabolic
                      rate across the tested ages. This work supports the
                      significance of choroid plexus function for brain aging and
                      promotes this tissue as a future target for
                      neurodegenerative diseases associated with impaired waste
                      clearance and cognitive decline.},
      keywords     = {Animals / Choroid Plexus: metabolism / Choroid Plexus:
                      physiology / Aging: metabolism / Male / Rats / Cerebrospinal
                      Fluid: metabolism / Intracranial Pressure: physiology /
                      Brain: metabolism / Transcriptome},
      cin          = {B410},
      ddc          = {500},
      cid          = {I:(DE-He78)B410-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40701965},
      doi          = {10.1038/s41467-025-61889-6},
      url          = {https://inrepo02.dkfz.de/record/303082},
}