%0 Journal Article
%A Holz, Anja
%A Obi, Nadia
%A Pischon, Tobias
%A Schulze, Matthias B
%A Ahrens, Wolfgang
%A Berger, Klaus
%A Bohn, Barbara
%A Brenner, Hermann
%A Emmel, Carina
%A Fischer, Beate
%A Greiser, Karin Halina
%A Harth, Volker
%A Holleczek, Bernd
%A Kaaks, Rudolf
%A Karch, André
%A Katzke, Verena
%A Keil, Thomas
%A Krist, Lilian
%A Leitzmann, Michael
%A Meinke-Franze, Claudia
%A Michels, Karin B
%A Nimptsch, Katharina
%A Peters, Annette
%A Riedel, Oliver
%A Schikowski, Tamara
%A Schipf, Sabine
%A Schmidt, Börge
%A Thierry, Sigrid
%A Hellwig, Kerstin
%A Riemann-Lorenz, Karin
%A Heesen, Christoph
%A Becher, Heiko
%T The Relation of Multiple Sclerosis to Family History, Lifestyle, and Health Factors in Childhood and Adolescence: Findings of a Case-Control Study Nested Within the German National Cohort (NAKO) Study.
%J Deutsches Ärzteblatt international
%V 112
%N 13
%@ 1866-0452
%C Köln
%I Dt. Ärzte-Verl.
%M DKFZ-2025-01524
%P 348-354
%D 2025
%X Multiple sclerosis (MS) is a neuroinflammatory disease of presumed autoimmune origin. A combination of genetic susceptibility and exposure to certain environmental and lifestyle factors might trigger the onset of MS. The currently known risk factors include a genetic predisposition, infection with the Epstein-Barr virus (EBV), smoking, and an increased body mass index.In 2021-22, we carried out a case-control study nested within the German National Cohort (NAKO) to investigate associations of potential risk factors with MS.The subjects included 576 persons with MS (cases) and 895 without MS (controls). Beyond the known risk factors, we observed associations between MS and the cumulative number of common childhood infections (odds ratio (OR) 1.14 per additional infection, 95
%K Humans
%K Multiple Sclerosis: epidemiology
%K Multiple Sclerosis: genetics
%K Multiple Sclerosis: etiology
%K Female
%K Male
%K Case-Control Studies
%K Germany: epidemiology
%K Adolescent
%K Life Style
%K Child
%K Risk Factors
%K Adult
%K Cohort Studies
%K Middle Aged
%K Young Adult
%K Genetic Predisposition to Disease: epidemiology
%K Child, Preschool
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40392126
%R 10.3238/arztebl.m2025.0069
%U https://inrepo02.dkfz.de/record/303099