The Relation of Multiple Sclerosis to Family History, Lifestyle, and Health Factors in Childhood and Adolescence: Findings of a Case-Control Study Nested Within the German National Cohort (NAKO) Study.

Holz, Anja; Kaaks, Rudolf; Meinke-Franze, Claudia; Keil, Thomas; Nimptsch, Katharina; Berger, Klaus; Karch, André; Riemann-Lorenz, Karin; Obi, Nadia; Hellwig, Kerstin; Bohn, Barbara; Michels, Karin B; Thierry, Sigrid; Peters, Annette; Ahrens, Wolfgang; Pischon, Tobias; Greiser, Karin Halina; Schipf, Sabine; Schmidt, Börge; Leitzmann, Michael; Brenner, Hermann; Harth, Volker; Becher, Heiko; Schikowski, Tamara; Fischer, Beate; Emmel, Carina; Riedel, Oliver; Katzke, Verena; Heesen, Christoph; Holleczek, Bernd; Schulze, Matthias B; Krist, Lilian

doi:10.3238/arztebl.m2025.0069

TY  - JOUR
AU  - Holz, Anja
AU  - Obi, Nadia
AU  - Pischon, Tobias
AU  - Schulze, Matthias B
AU  - Ahrens, Wolfgang
AU  - Berger, Klaus
AU  - Bohn, Barbara
AU  - Brenner, Hermann
AU  - Emmel, Carina
AU  - Fischer, Beate
AU  - Greiser, Karin Halina
AU  - Harth, Volker
AU  - Holleczek, Bernd
AU  - Kaaks, Rudolf
AU  - Karch, André
AU  - Katzke, Verena
AU  - Keil, Thomas
AU  - Krist, Lilian
AU  - Leitzmann, Michael
AU  - Meinke-Franze, Claudia
AU  - Michels, Karin B
AU  - Nimptsch, Katharina
AU  - Peters, Annette
AU  - Riedel, Oliver
AU  - Schikowski, Tamara
AU  - Schipf, Sabine
AU  - Schmidt, Börge
AU  - Thierry, Sigrid
AU  - Hellwig, Kerstin
AU  - Riemann-Lorenz, Karin
AU  - Heesen, Christoph
AU  - Becher, Heiko
TI  - The Relation of Multiple Sclerosis to Family History, Lifestyle, and Health Factors in Childhood and Adolescence: Findings of a Case-Control Study Nested Within the German National Cohort (NAKO) Study.
JO  - Deutsches Ärzteblatt international
VL  - 112
IS  - 13
SN  - 1866-0452
CY  - Köln
PB  - Dt. Ärzte-Verl.
M1  - DKFZ-2025-01524
SP  - 348-354
PY  - 2025
AB  - Multiple sclerosis (MS) is a neuroinflammatory disease of presumed autoimmune origin. A combination of genetic susceptibility and exposure to certain environmental and lifestyle factors might trigger the onset of MS. The currently known risk factors include a genetic predisposition, infection with the Epstein-Barr virus (EBV), smoking, and an increased body mass index.In 2021-22, we carried out a case-control study nested within the German National Cohort (NAKO) to investigate associations of potential risk factors with MS.The subjects included 576 persons with MS (cases) and 895 without MS (controls). Beyond the known risk factors, we observed associations between MS and the cumulative number of common childhood infections (odds ratio (OR) 1.14 per additional infection, 95
KW  - Humans
KW  - Multiple Sclerosis: epidemiology
KW  - Multiple Sclerosis: genetics
KW  - Multiple Sclerosis: etiology
KW  - Female
KW  - Male
KW  - Case-Control Studies
KW  - Germany: epidemiology
KW  - Adolescent
KW  - Life Style
KW  - Child
KW  - Risk Factors
KW  - Adult
KW  - Cohort Studies
KW  - Middle Aged
KW  - Young Adult
KW  - Genetic Predisposition to Disease: epidemiology
KW  - Child, Preschool
LB  - PUB:(DE-HGF)16
C6  - pmid:40392126
DO  - DOI:10.3238/arztebl.m2025.0069
UR  - https://inrepo02.dkfz.de/record/303099
ER  -

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