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@ARTICLE{Oster:303111,
      author       = {C. Oster$^*$ and A. Matyar and T. Schmidt and T. Hummel and
                      E. Hattingen and M. Jokisch and D. Jokisch and J. Grieger
                      and G. Cappello and K. Kizina and L. Lazaridis and Y.
                      Ahmadipour and L. Rauschenbach$^*$ and M. Stuschke and C.
                      Pöttgen and N. Guberina and T. Tertel and B. Giebel and G.
                      L. Dreizner and F. Barbato$^*$ and E.-M. Skoda and B.
                      Scheffler$^*$ and M. Müther and K. Herrmann$^*$ and C.
                      Kleinschnitz and U. Sure and C. Deuschl and M. Glas$^*$ and
                      S. Kebir},
      title        = {{D}ecoding glioblastoma survival: unraveling the prognostic
                      potential of olfactory function in a prospective
                      observational study.},
      journal      = {Neurological research and practice},
      volume       = {7},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2025-01530},
      pages        = {51},
      year         = {2025},
      abstract     = {Olfactory impairment is common in glioblastoma and has been
                      associated with unfavorable overall survival. However, prior
                      studies were limited by imbalances in key prognostic factors
                      and the absence of longitudinal olfactory assessments to
                      evaluate treatment-related neurotoxicity. The aim of the
                      study is to determine whether olfactory function serves as
                      an independent prognostic marker for survival,
                      neurocognitive outcomes, and quality of life in
                      glioblastoma.Prospective, multicenter cohort study enrolling
                      64 glioblastoma patients and 64 matched healthy controls.
                      Patients are stratified by extent of resection,
                      O6-Methylguanine-DNA Methyltransferase promoter methylation,
                      radiographic involvement of olfactory regions, baseline
                      olfactory status, age, and Karnofsky performance status.
                      Olfactory function is assessed serially using Sniffin'
                      Sticks (identification and threshold tests) from diagnosis
                      through treatment. Coronal T2- and T1-weighted MRI scans are
                      reviewed independently by two blinded neuroradiologists to
                      detect olfactory region involvement. Neurocognitive testing,
                      psychosocial screening, and quality of life assessments are
                      conducted at defined intervals. Next-generation sequencing
                      from tumor tissue is employed to explore molecular
                      underpinnings of hyposmia. Blood samples are collected in
                      every study visit for potential parallel translational
                      studies.This is the first longitudinal study evaluating
                      olfactory function as a prognostic biomarker in
                      glioblastoma. Findings may inform risk stratification, guide
                      neuroprotective strategies, and improve survivorship
                      care.ClinicalTrials.gov, NCT06954636, date of registration
                      04-16-2025 (retrospectively registered);
                      $https://clinicaltrials.gov/study/NCT06954636?cond=glioblastoma\&intr=olfactory\&rank=1$
                      .},
      keywords     = {Glioblastoma (Other) / Identification test (Other) /
                      Olfactory dysfunction (Other) / Prognosis (Other) /
                      Threshold test (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40708059},
      doi          = {10.1186/s42466-025-00410-2},
      url          = {https://inrepo02.dkfz.de/record/303111},
}