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@ARTICLE{Ding:303119,
      author       = {J. Ding$^*$ and B. Schöttker$^*$ and H. Brenner$^*$ and M.
                      Hoffmeister$^*$},
      title        = {{T}hirteen simple lifestyle scores and risk of cancer,
                      cardiovascular disease, diabetes, and mortality:
                      {P}rospective cohort study in the {UK} {B}iobank.},
      journal      = {International journal of cancer},
      volume       = {nn},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2025-01538},
      pages        = {nn},
      year         = {2025},
      note         = {#EA:C070#LA:C070# / epub},
      abstract     = {Numerous simple lifestyle scores have been developed for
                      specific non-communicable diseases (NCDs). This research
                      aimed to investigate and compare the associations of various
                      lifestyle scores with the incidence and mortality of NCDs.
                      In 76,399 participants from the UK Biobank, we investigated
                      the associations of 13 lifestyle scores with the incidence
                      and mortality of cancer, cardiovascular disease (CVD), type
                      2 diabetes (T2D), and a composite of these NCDs. Cox
                      proportional-hazards regression models were used to estimate
                      hazard ratios (HRs) for associations between lifestyle
                      scores and NCD outcomes. During a median follow-up time of
                      10.5 years, 12,214 incident NCD cases and 2250 NCD deaths
                      were documented. Higher lifestyle scores were generally
                      associated with a reduced risk of overall NCDs (HRs ranging
                      from 0.65 to 0.89) and NCD mortality (0.51-0.92). Cancer
                      (HRs ranging from 0.72 to 0.98) and CVD (0.55-0.87) risk
                      were less dependent on lifestyle behaviors than T2D
                      (0.18-0.74). Notably, the top three scores associated with
                      cancer outcomes included smoking as a component, and those
                      for T2D included body mass index (BMI). For overall NCD
                      outcomes, lifestyle scores including both smoking and BMI
                      showed the strongest associations. Healthy Lifestyle Score
                      and the Chronic Disease Risk Index were the overall
                      best-performing scores to predict NCD risk and mortality.
                      These findings suggest that the use of lifestyle scores
                      designed for a single disease group can be extended for
                      predicting multiple NCDs and mortality. Both smoking and BMI
                      should be included in lifestyle scores aiming to predict
                      overall NCD risk and mortality for future research and
                      recommendations.},
      keywords     = {cancer (Other) / cardiovascular diseases (Other) /
                      lifestyle (Other) / non‐communicable diseases (Other) /
                      type 2 diabetes (Other)},
      cin          = {C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40704764},
      doi          = {10.1002/ijc.70064},
      url          = {https://inrepo02.dkfz.de/record/303119},
}