%0 Journal Article
%A Cui, Zhixin
%A Schomburg, Lutz
%A Holleczek, Bernd
%A Hybsier, Sandra
%A Köhrle, Josef
%A Brenner, Hermann
%A Schöttker, Ben
%T Serum selenoprotein P concentrations and cardiovascular disease: results from a large, prospective cohort study of older German adults.
%J Free radical biology and medicine
%V 239
%@ 0891-5849
%C New York, NY [u.a.]
%I Elsevier
%M DKFZ-2025-01586
%P 270-279
%D 2025
%Z #EA:C070#LA:C070# / Volume 239, November 2025, Pages 270-279
%X Studies on the association of selenoprotein P (SELENOP) with cardiovascular outcomes yielded inconsistent results. We assessed the association of SELENOP serum levels with cardiovascular disease (CVD), stroke and coronary heart disease (CHD) in CVD-free adults and the association with CVD mortality in CVD patients.Serum SELENOP concentrations were measured at baseline and 5-year follow-up in 6,600 CVD-free participants and 1,729 CVD patients aged 50-74 years from the German ESTHER study. Multivariable Cox models were performed.During 17 years of follow-up, 1,837 CVD-free participants developed CVD, of whom 675 had a stroke and 1,153 were diagnosed with CHD, and 352 CVD patients died from CVD. In the multivariable Cox model, CVD-free participants in the lowest SELENOP quartile had a 1.5-fold higher stroke risk than those in the highest quartile (HR [95
%K Cardiovascular Diseases (Other)
%K Cohort Studies (Other)
%K Coronary Disease (Other)
%K Mortality (Other)
%K Selenoprotein P (Other)
%K Stroke (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40738180
%R 10.1016/j.freeradbiomed.2025.07.039
%U https://inrepo02.dkfz.de/record/303240