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000303240 1001_ $$0P:(DE-He78)a9f5a6e80270aef6347a340d52c893c1$$aCui, Zhixin$$b0$$eFirst author$$udkfz
000303240 245__ $$aSerum selenoprotein P concentrations and cardiovascular disease: results from a large, prospective cohort study of older German adults.
000303240 260__ $$aNew York, NY [u.a.]$$bElsevier$$c2025
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000303240 500__ $$a#EA:C070#LA:C070# / Volume 239, November 2025, Pages 270-279
000303240 520__ $$aStudies on the association of selenoprotein P (SELENOP) with cardiovascular outcomes yielded inconsistent results. We assessed the association of SELENOP serum levels with cardiovascular disease (CVD), stroke and coronary heart disease (CHD) in CVD-free adults and the association with CVD mortality in CVD patients.Serum SELENOP concentrations were measured at baseline and 5-year follow-up in 6,600 CVD-free participants and 1,729 CVD patients aged 50-74 years from the German ESTHER study. Multivariable Cox models were performed.During 17 years of follow-up, 1,837 CVD-free participants developed CVD, of whom 675 had a stroke and 1,153 were diagnosed with CHD, and 352 CVD patients died from CVD. In the multivariable Cox model, CVD-free participants in the lowest SELENOP quartile had a 1.5-fold higher stroke risk than those in the highest quartile (HR [95%CI], 1.58 [1.17-2.12]). Associations with CVD incidence were only observed in patients with hypertension (HR [95%CI], 1.21 [1.03-1.41]) or diabetes (HR [95%CI], 1.36 [1.01-1.83]). No association was observed between SELENOP concentrations and CHD incidence. Furthermore, CVD patients in the lowest SELENOP quartile had an almost 2-fold increased CVD mortality compared to the rest (HR [95%CI], 1.85 [1.31-2.60]).Low serum SELENOP concentrations were associated with an increased risk of stroke in subjects free of CVD and with CVD mortality among CVD patients. The association of SELENOP concentrations with CVD incidence was restricted to patients with hypertension or diabetes. Well-designed trials are required to assess potential preventive effects of selenium supplementation.
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000303240 650_7 $$2Other$$aCardiovascular Diseases
000303240 650_7 $$2Other$$aCohort Studies
000303240 650_7 $$2Other$$aCoronary Disease
000303240 650_7 $$2Other$$aMortality
000303240 650_7 $$2Other$$aSelenoprotein P
000303240 650_7 $$2Other$$aStroke
000303240 7001_ $$aSchomburg, Lutz$$b1
000303240 7001_ $$aHolleczek, Bernd$$b2
000303240 7001_ $$aHybsier, Sandra$$b3
000303240 7001_ $$aKöhrle, Josef$$b4
000303240 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b5$$udkfz
000303240 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b6$$eLast author$$udkfz
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