TY  - JOUR
AU  - Cui, Zhixin
AU  - Schomburg, Lutz
AU  - Holleczek, Bernd
AU  - Hybsier, Sandra
AU  - Köhrle, Josef
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Serum selenoprotein P concentrations and cardiovascular disease: results from a large, prospective cohort study of older German adults.
JO  - Free radical biology and medicine
VL  - 239
SN  - 0891-5849
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - DKFZ-2025-01586
SP  - 270-279
PY  - 2025
N1  - #EA:C070#LA:C070# / Volume 239, November 2025, Pages 270-279
AB  - Studies on the association of selenoprotein P (SELENOP) with cardiovascular outcomes yielded inconsistent results. We assessed the association of SELENOP serum levels with cardiovascular disease (CVD), stroke and coronary heart disease (CHD) in CVD-free adults and the association with CVD mortality in CVD patients.Serum SELENOP concentrations were measured at baseline and 5-year follow-up in 6,600 CVD-free participants and 1,729 CVD patients aged 50-74 years from the German ESTHER study. Multivariable Cox models were performed.During 17 years of follow-up, 1,837 CVD-free participants developed CVD, of whom 675 had a stroke and 1,153 were diagnosed with CHD, and 352 CVD patients died from CVD. In the multivariable Cox model, CVD-free participants in the lowest SELENOP quartile had a 1.5-fold higher stroke risk than those in the highest quartile (HR [95
KW  - Cardiovascular Diseases (Other)
KW  - Cohort Studies (Other)
KW  - Coronary Disease (Other)
KW  - Mortality (Other)
KW  - Selenoprotein P (Other)
KW  - Stroke (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40738180
DO  - DOI:10.1016/j.freeradbiomed.2025.07.039
UR  - https://inrepo02.dkfz.de/record/303240
ER  -