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| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Furtner, Julia |b 0 |
| 245 | _ | _ | |a Prognostic value of 1D, 2D, and volumetric tumor size increases in recurrent WHO grade 2 and 3 meningiomas: Radiological post-hoc analysis of the EORTC-BTG-1320 trial. |
| 260 | _ | _ | |a Oxford |c 2025 |b Oxford University Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1753965525_19398 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a Although the differential prognostic value of 1D, 2D, and volumetric meningioma size assessment has been reported, RANO meningioma criteria rely on bidimensional measurements.In this post-hoc analysis of the EORTC-BTG 1320 trial, contrast-enhancing CNS WHO grade 2 and 3 meningiomas were assessed using 1D, 2D, and volumetric measurements. Different cutoff values for lesion size increase were compared 6 months after the start of antineoplastic treatment using Cox proportional hazards models to evaluate their association with overall survival (OS). Optimal cutoff values were identified using two criteria: maximal hazard ratio (HR) for death with statistical significance for median OS and the cutoff that maximized mean specificity and sensitivity for predicting 1-year OS.Among 57 evaluable patients, unidimensional 5 mm and 10 mm tumor size increase yielded the maximal HRs (HR = 3.41, 95% Confidence Interval (CI) 1.56-7.45, P < .01 and HR = 3.22, 95% CI 1.58-6.58, P < .01, respectively) for OS. A 6 mm tumor size increase maximized mean specificity and sensitivity (HR = 2.91, 95% CI 1.43-5.93, P < .01) for predicting 1-year OS. For tumor volume assessments, a 30% increase was associated with the maximal HR (HR = 3.69, 95% CI 1.64-8.31, P < .01) for OS whereas a 40% increase maximized the mean specificity and sensitivity (HR = 3.66, 95% CI 1.75-7.654, P < .01). Bidimensional measurements showed no significant OS association.Unidimensional tumor measurements and tumor volume assessments show a stronger association with overall survival than bidimensional measurements in recurrent non-benign meningiomas. Integration of these methods into response assessment criteria for meningiomas should be considered. |
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| 650 | _ | 7 | |a MRI |2 Other |
| 650 | _ | 7 | |a meningioma |2 Other |
| 650 | _ | 7 | |a progression |2 Other |
| 650 | _ | 7 | |a survival |2 Other |
| 700 | 1 | _ | |a Berchtold, Luzia |b 1 |
| 700 | 1 | _ | |a Le Rhun, Emilie |0 0000-0002-9408-3278 |b 2 |
| 700 | 1 | _ | |a Silvani, Antonio |b 3 |
| 700 | 1 | _ | |a Rudà, Roberta |b 4 |
| 700 | 1 | _ | |a Lombardi, Giuseppe |0 0000-0003-1316-2132 |b 5 |
| 700 | 1 | _ | |a Sepúlveda-Sánchez, Juan Manuel |b 6 |
| 700 | 1 | _ | |a Brandal, Petter |0 0000-0003-0259-495X |b 7 |
| 700 | 1 | _ | |a Bendszus, Martin |b 8 |
| 700 | 1 | _ | |a Golfinopoulos, Vassilis |b 9 |
| 700 | 1 | _ | |a Gorlia, Thierry |b 10 |
| 700 | 1 | _ | |a Sahm, Felix |0 P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88 |b 11 |u dkfz |
| 700 | 1 | _ | |a Wick, Wolfgang |0 P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee |b 12 |u dkfz |
| 700 | 1 | _ | |a Minniti, Giuseppe |b 13 |
| 700 | 1 | _ | |a Weller, Michael |0 0000-0002-1748-174X |b 14 |
| 700 | 1 | _ | |a König, Franz |b 15 |
| 700 | 1 | _ | |a Preusser, Matthias |0 0000-0003-3541-2315 |b 16 |
| 773 | _ | _ | |a 10.1093/noajnl/vdaf152 |g Vol. 7, no. 1, p. vdaf152 |0 PERI:(DE-600)3009682-0 |n 1 |p vdaf152 |t Neuro-oncology advances |v 7 |y 2025 |x 2632-2498 |
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