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@ARTICLE{Faria:303255,
      author       = {C. Faria and C. Dobano-Lopez$^*$ and P. Pérez-Galán and
                      C. Bezombes},
      title        = {{G}oodbye flat lymphoma biology.},
      journal      = {FEBS letters},
      volume       = {nn},
      issn         = {0014-5793},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {DKFZ-2025-01600},
      pages        = {nn},
      year         = {2025},
      note         = {#EA:B060# / epub},
      abstract     = {B-cell lymphomas grow in aggregates, closely interacting
                      with specific physical elements and cellular environments.
                      While 2D culture systems have long been the standard in the
                      field, current methodologies aim to better replicate
                      lymphoma biology and its microenvironment in 3D. Significant
                      progress has been made since the first 3D lymphoma cell line
                      culture was developed in 2012. Subsequent advances in both
                      cell line and patient-derived systems have incorporated key
                      physical and cellular microenvironmental components. This
                      Review compiles the relevant 3D non-Hodgkin lymphoma models
                      available, outlining their main features, strengths, and
                      limitations. Additionally, we highlight the critical gaps
                      that must be addressed to develop robust, multiplexed,
                      patient-derived B-cell lymphoma systems, which can serve as
                      reliable avatars alongside clinical trials and contribute to
                      the principles of the 3Rs in animal research. Impact
                      statement In the last few years new B-cell lymphoma 3D
                      models have emerged, with a special emphasis on
                      patient-derived models. These systems are fundamental tools
                      for precision medicine. This review provides translational
                      researchers and clinician scientists with an excellent
                      overview of these novel tools with their strong and weak
                      points.},
      subtyp        = {Review Article},
      keywords     = {diffuse large B‐cell lymphoma (Other) / follicular
                      lymphoma (Other) / lymphoma‐on‐chip (Other) / mantle
                      cell lymphoma (Other) / non‐Hodgkin lymphoma (Other) /
                      patient‐derived lymphoma models (Other) / preclinical 3D
                      models (Other)},
      cin          = {B060},
      ddc          = {610},
      cid          = {I:(DE-He78)B060-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40741889},
      doi          = {10.1002/1873-3468.70114},
      url          = {https://inrepo02.dkfz.de/record/303255},
}