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000303366 041__ $$aEnglish
000303366 082__ $$a610
000303366 1001_ $$aShimba, Akihiro$$b0
000303366 245__ $$aStress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells.
000303366 260__ $$aMaryland Heights, MO$$bCell Press$$c2025
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000303366 520__ $$aStress can trigger acute inflammation by increasing the pro-inflammatory cytokine interleukin (IL)-17 for injury and infection, while inducing the production of the immunosuppressive hormone glucocorticoids (GCs). However, the mechanism through which stress-induced GCs enhance acute inflammation by directly regulating the development of IL-17-producing helper T (Th17) cells remains unclear. Here, we demonstrate that GCs promote Th17 cell differentiation and survival in both mice and humans. Stress-induced GCs augment the expansion of Th17 cells expressing low levels of TCF1, a negative regulator of IL-17 expression. In addition, GCs promote Th17 cell differentiation by enhancing glycolysis. Stress-induced GCs also increase IL-17 production and neutrophil recruitment in the intestine upon bacterial antigen stimulation. Moreover, the expansion of Th17 cells mediated by stress-induced GCs exacerbates acute colitis by promoting IL-17 production and neutrophil recruitment. Thus, stress promotes acute inflammation by enhancing the differentiation of Th17 cells through GCs, which may contribute to self-defense against infections.
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000303366 650_7 $$2Other$$aCP: Immunology
000303366 650_7 $$2Other$$aIL-17
000303366 650_7 $$2Other$$aTh17
000303366 650_7 $$2Other$$acolitis
000303366 650_7 $$2Other$$aglucocorticoid
000303366 650_7 $$2Other$$aneutrophil
000303366 650_7 $$2Other$$astress
000303366 7001_ $$aCui, Guangwei$$b1
000303366 7001_ $$aAbe, Shinya$$b2
000303366 7001_ $$aHirota, Keiji$$b3
000303366 7001_ $$aMiyauchi, Eiji$$b4
000303366 7001_ $$aTakami, Daichi$$b5
000303366 7001_ $$aTani-Ichi, Shizue$$b6
000303366 7001_ $$aKato, Ryoma$$b7
000303366 7001_ $$aTajima, Masaki$$b8
000303366 7001_ $$aKanahashi, Toru$$b9
000303366 7001_ $$aMiyazaki, Masaki$$b10
000303366 7001_ $$0P:(DE-He78)86fa3316b7be0d661065d02b3baec3d6$$aRodewald, Hans-Reimer$$b11$$udkfz
000303366 7001_ $$aYoshitomi, Hiroyuki$$b12
000303366 7001_ $$aUeno, Hideki$$b13
000303366 7001_ $$aOhno, Hiroshi$$b14
000303366 7001_ $$aIkuta, Koichi$$b15
000303366 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2025.116093$$gVol. 44, no. 8, p. 116093 -$$n8$$p116093$$tCell reports$$v44$$x2211-1247$$y2025
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