TY  - JOUR
AU  - Shimba, Akihiro
AU  - Cui, Guangwei
AU  - Abe, Shinya
AU  - Hirota, Keiji
AU  - Miyauchi, Eiji
AU  - Takami, Daichi
AU  - Tani-Ichi, Shizue
AU  - Kato, Ryoma
AU  - Tajima, Masaki
AU  - Kanahashi, Toru
AU  - Miyazaki, Masaki
AU  - Rodewald, Hans-Reimer
AU  - Yoshitomi, Hiroyuki
AU  - Ueno, Hideki
AU  - Ohno, Hiroshi
AU  - Ikuta, Koichi
TI  - Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells.
JO  - Cell reports
VL  - 44
IS  - 8
SN  - 2211-1247
CY  - Maryland Heights, MO
PB  - Cell Press
M1  - DKFZ-2025-01616
SP  - 116093
PY  - 2025
AB  - Stress can trigger acute inflammation by increasing the pro-inflammatory cytokine interleukin (IL)-17 for injury and infection, while inducing the production of the immunosuppressive hormone glucocorticoids (GCs). However, the mechanism through which stress-induced GCs enhance acute inflammation by directly regulating the development of IL-17-producing helper T (Th17) cells remains unclear. Here, we demonstrate that GCs promote Th17 cell differentiation and survival in both mice and humans. Stress-induced GCs augment the expansion of Th17 cells expressing low levels of TCF1, a negative regulator of IL-17 expression. In addition, GCs promote Th17 cell differentiation by enhancing glycolysis. Stress-induced GCs also increase IL-17 production and neutrophil recruitment in the intestine upon bacterial antigen stimulation. Moreover, the expansion of Th17 cells mediated by stress-induced GCs exacerbates acute colitis by promoting IL-17 production and neutrophil recruitment. Thus, stress promotes acute inflammation by enhancing the differentiation of Th17 cells through GCs, which may contribute to self-defense against infections.
KW  - CP: Immunology (Other)
KW  - IL-17 (Other)
KW  - Th17 (Other)
KW  - colitis (Other)
KW  - glucocorticoid (Other)
KW  - neutrophil (Other)
KW  - stress (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40753571
DO  - DOI:10.1016/j.celrep.2025.116093
UR  - https://inrepo02.dkfz.de/record/303366
ER  -