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000303377 1001_ $$00000-0002-1781-7127$$aZhang, Zhenhua$$b0
000303377 245__ $$aUnveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions.
000303377 260__ $$a[London]$$bSpringer Nature$$c2025
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000303377 520__ $$aDeciphering the intricate regulatory mechanisms underlying biological processes holds promise for elucidating how genetic variants contribute to immune-related disorders. We map genetic effects on gene expression (expression quantitative trait locus, eQTL) using single-cell transcriptomes of 152 samples from 38 healthy individuals, covering baseline state and lipopolysaccharide challenge either before or after Bacillus Calmette-Guerin vaccination. Interestingly, we uncover a monocyte eQTL linked to the LCP1, shedding light on inter-individual variations in trained immunity. Furthermore, we elucidate genetic and epigenetic regulatory networks of CD55 and SLFN5. Of note, our results support the pivotal roles of SLFN5 in COVID-19 pathogenesis by incorporating disease-associated loci, chromatin accessibility, and transcription factor binding affinities, aligning with the established functions of SLFN5 in restricting virus replication during viral infection. Our study provides a paradigm to decipher genetic underpinnings of complex traits by integrating single-cell eQTLs with multi-omics data from patients and public databases.
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000303377 650_2 $$2MeSH$$aHumans
000303377 650_2 $$2MeSH$$aQuantitative Trait Loci: genetics
000303377 650_2 $$2MeSH$$aSingle-Cell Analysis: methods
000303377 650_2 $$2MeSH$$aCOVID-19: immunology
000303377 650_2 $$2MeSH$$aCOVID-19: genetics
000303377 650_2 $$2MeSH$$aCOVID-19: virology
000303377 650_2 $$2MeSH$$aSARS-CoV-2: immunology
000303377 650_2 $$2MeSH$$aTranscriptome
000303377 650_2 $$2MeSH$$aMale
000303377 650_2 $$2MeSH$$aFemale
000303377 650_2 $$2MeSH$$aGene Regulatory Networks
000303377 650_2 $$2MeSH$$aMonocytes: immunology
000303377 650_2 $$2MeSH$$aMonocytes: metabolism
000303377 650_2 $$2MeSH$$aImmune System Diseases: genetics
000303377 650_2 $$2MeSH$$aImmune System Diseases: immunology
000303377 650_2 $$2MeSH$$aAdult
000303377 650_2 $$2MeSH$$aImmunity: genetics
000303377 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000303377 7001_ $$00000-0002-7956-0742$$aLi, Wenchao$$b1
000303377 7001_ $$aZhan, Qiuyao$$b2
000303377 7001_ $$aAillaud, Michelle$$b3
000303377 7001_ $$00000-0003-3512-3150$$aBotey-Bataller, Javier$$b4
000303377 7001_ $$00000-0003-3636-2209$$aZoodsma, Martijn$$b5
000303377 7001_ $$00000-0003-0576-5873$$aTer Horst, Rob$$b6
000303377 7001_ $$00000-0001-6166-9830$$aJoosten, Leo A B$$b7
000303377 7001_ $$00000-0001-6091-3088$$aBock, Christoph$$b8
000303377 7001_ $$00000-0001-6814-9344$$aSchulte, Leon N$$b9
000303377 7001_ $$00000-0003-1586-4672$$aXu, Cheng-Jian$$b10
000303377 7001_ $$00000-0003-2421-6052$$aNetea, Mihai G$$b11
000303377 7001_ $$0P:(DE-He78)ed3a2ed903bfbc6b0c33ef7009b141ce$$aBonder, Marc Jan$$b12
000303377 7001_ $$00000-0003-4022-7341$$aLi, Yang$$b13
000303377 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-61192-4$$gVol. 16, no. 1, p. 7134$$n1$$p7134$$tNature Communications$$v16$$x2041-1723$$y2025
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