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000303402 1001_ $$0P:(DE-HGF)0$$aFoerster, Leo Carl$$b0$$eFirst author
000303402 245__ $$aCross-species comparison reveals therapeutic vulnerabilities halting glioblastoma progression.
000303402 260__ $$a[London]$$bSpringer Nature$$c2025
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000303402 520__ $$aThe growth of a tumor is tightly linked to the distribution of its cells along a continuum of activation states. Here, we systematically decode the activation state architecture (ASA) in a glioblastoma (GBM) patient cohort through comparison to adult murine neural stem cells. Modelling of these data forecasts how tumor cells organize to sustain growth and identifies the rate of activation as the main predictor of growth. Accordingly, patients with a higher quiescence fraction exhibit improved outcomes. Further, DNA methylation arrays enable ASA-related patient stratification. Comparison of healthy and malignant gene expression dynamics reveals dysregulation of the Wnt-antagonist SFRP1 at the quiescence to activation transition. SFRP1 overexpression renders GBM quiescent and increases the overall survival of tumor-bearing mice. Surprisingly, it does so through reprogramming the tumor's stem-like methylome into an astrocyte-like one. Our findings offer a framework for patient stratification with prognostic value, biomarker identification, and therapeutic avenues to halt GBM progression.
000303402 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
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000303402 650_7 $$2NLM Chemicals$$aMembrane Proteins
000303402 650_7 $$2NLM Chemicals$$aIntercellular Signaling Peptides and Proteins
000303402 650_7 $$2NLM Chemicals$$aSFRP1 protein, human
000303402 650_2 $$2MeSH$$aGlioblastoma: genetics
000303402 650_2 $$2MeSH$$aGlioblastoma: pathology
000303402 650_2 $$2MeSH$$aGlioblastoma: metabolism
000303402 650_2 $$2MeSH$$aHumans
000303402 650_2 $$2MeSH$$aAnimals
000303402 650_2 $$2MeSH$$aMice
000303402 650_2 $$2MeSH$$aDNA Methylation
000303402 650_2 $$2MeSH$$aDisease Progression
000303402 650_2 $$2MeSH$$aBrain Neoplasms: pathology
000303402 650_2 $$2MeSH$$aBrain Neoplasms: genetics
000303402 650_2 $$2MeSH$$aBrain Neoplasms: metabolism
000303402 650_2 $$2MeSH$$aGene Expression Regulation, Neoplastic
000303402 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000303402 650_2 $$2MeSH$$aMembrane Proteins: genetics
000303402 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000303402 650_2 $$2MeSH$$aNeural Stem Cells: pathology
000303402 650_2 $$2MeSH$$aIntercellular Signaling Peptides and Proteins: metabolism
000303402 650_2 $$2MeSH$$aIntercellular Signaling Peptides and Proteins: genetics
000303402 650_2 $$2MeSH$$aCell Line, Tumor
000303402 650_2 $$2MeSH$$aNeoplastic Stem Cells: metabolism
000303402 650_2 $$2MeSH$$aNeoplastic Stem Cells: pathology
000303402 650_2 $$2MeSH$$aFemale
000303402 650_2 $$2MeSH$$aMale
000303402 650_2 $$2MeSH$$aSpecies Specificity
000303402 650_2 $$2MeSH$$aPrognosis
000303402 7001_ $$0P:(DE-He78)6d17c3c17f328bb0390e292d55dbd0aa$$aKaya, Oguzhan$$b1$$eFirst author
000303402 7001_ $$00009-0009-3955-9323$$aWüst, Valentin$$b2
000303402 7001_ $$aDanciu, Diana-Patricia$$b3
000303402 7001_ $$0P:(DE-He78)1d5fe6d062033e9f04f90c522a9e4a45$$aAkçay, Vuslat$$b4$$udkfz
000303402 7001_ $$0P:(DE-He78)77255885592a5504629548dfa94bd8e1$$aBekavac, Milica$$b5$$udkfz
000303402 7001_ $$0P:(DE-He78)ac691a4aa8da997d7f442e0ed17127c5$$aZiegler, Kevin Chris$$b6
000303402 7001_ $$0P:(DE-He78)8d19d7135a30eb70b79e144a12f17d0f$$aStinchcombe, Nina$$b7$$udkfz
000303402 7001_ $$0P:(DE-HGF)0$$aTang, Anna$$b8
000303402 7001_ $$0P:(DE-He78)28e985c17b8005075622a848fe38b206$$aKleber, Susanne$$b9$$udkfz
000303402 7001_ $$0P:(DE-HGF)0$$aTang, Joceyln$$b10
000303402 7001_ $$0P:(DE-He78)ae499fa5f2cb516077d2a80afe84fa2d$$aBrunken, Jan$$b11$$udkfz
000303402 7001_ $$0P:(DE-HGF)0$$aLois-Bermejo, Irene$$b12
000303402 7001_ $$0P:(DE-HGF)0$$aGesteira-Perez, Noelia$$b13
000303402 7001_ $$0P:(DE-He78)88de8ba75b18dd92d742eb7eab04a1b3$$aMa, Xiujian$$b14
000303402 7001_ $$0P:(DE-He78)970bd627f415e0a127210d2cecf2311f$$aSadik, Ahmed$$b15$$udkfz
000303402 7001_ $$aLe, Phuong Uyen$$b16
000303402 7001_ $$00000-0002-8140-6402$$aPetrecca, Kevin$$b17
000303402 7001_ $$0P:(DE-He78)14aa02d2ca0515d0c53f1d6678e3ca34$$aOpitz, Christiane$$b18$$udkfz
000303402 7001_ $$0P:(DE-He78)76aeb2431f7458c9261e69c5420390c6$$aLiu, Haikun$$b19$$udkfz
000303402 7001_ $$aWirtz, Christian Rainer$$b20
000303402 7001_ $$00000-0002-3890-7658$$aGoncalves, Angela$$b21
000303402 7001_ $$00000-0002-5831-6505$$aMarciniak-Czochra, Anna$$b22
000303402 7001_ $$00000-0003-4868-1805$$aAnders, Simon$$b23
000303402 7001_ $$0P:(DE-He78)9f92f3ae36d92f7d6f070602e0e8585c$$aMartin-Villalba, Ana$$b24$$eLast author$$udkfz
000303402 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-62528-w$$gVol. 16, no. 1, p. 7250$$n1$$p7250$$tNature Communications$$v16$$x2041-1723$$y2025
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