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@ARTICLE{Rinne:303427,
      author       = {S. Rinne and B. Michels$^*$ and J. Butt$^*$ and K.
                      Syrjänen and S. Grenman and T. Waterboer$^*$ and S.
                      Syrjänen and K. Louvanto},
      title        = {{E}pstein-{B}arr {V}irus {S}erology {A}ssociated {W}ith
                      {P}ersistent {O}ral {H}uman {P}apillomavirus {I}nfections in
                      {M}en.},
      journal      = {Journal of oral pathology $\&$ medicine},
      volume       = {nn},
      issn         = {0300-9777},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2025-01652},
      pages        = {nn},
      year         = {2025},
      note         = {epub},
      abstract     = {Most people acquire Epstein-Barr virus (EBV) and certain
                      human papillomaviruses (HPVs) during their lifetime.
                      HPV-related oropharyngeal carcinomas have increased in
                      recent decades, particularly among men. The role of
                      coinfection with viruses like EBV on HPV outcomes is
                      unclear. We investigated potential associations between EBV
                      serology and longitudinal outcomes of oral HPV infections in
                      men.This study included 119 men from the Finnish Family HPV
                      Study who were followed up for 3 years. Blood and oral
                      cavity samples were collected at baseline, 12-, 24-, and
                      36-month follow-up visits. HPV was genotyped with the
                      Multimetrix assay, and the serum IgG antibodies of EBV
                      proteins Zebra, EA-D, EBNA, and VCAp18 were measured with
                      fluorescent bead-based multiplex serology. Univariate
                      regression analysis was used to measure the strength of the
                      association between different variables.Most participants
                      $(99.2\%;$ n = 118) were EBV-seropositive with stable
                      antibody titers throughout the follow-up. Self-reported
                      history of atopy was positively associated with elevated
                      EBNA-1 levels, with OR 7.43 $(95\%$ CI: 1.39-39.76). EBV
                      seropositivity with high titers and elevated EA-D levels
                      alone increased the risk of type-specific oral HPV
                      persistence for Types 16, 18, 33, and 51, with OR 4.20
                      $(95\%$ CI: 1.09-16.19) and OR 6.23 $(95\%$ CI: 1.19-32.75),
                      respectively.Most of the participants were EBV-seropositive
                      as expected. Elevated EA-D antibody levels and being
                      EBV-seropositive with high titers significantly increased
                      the risk of type-specific oral HPV persistence among these
                      men.},
      keywords     = {EBV antibodies (Other) / EBV serology (Other) /
                      Epstein–Barr virus (EBV) (Other) / human papillomavirus
                      (HPV) (Other) / oral HPV infections (Other)},
      cin          = {D320},
      ddc          = {610},
      cid          = {I:(DE-He78)D320-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40772503},
      doi          = {10.1111/jop.70015},
      url          = {https://inrepo02.dkfz.de/record/303427},
}