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@ARTICLE{Steiner:303444,
      author       = {J. M. Steiner and H. Algül and D. A. Ruess$^*$ and I. E.
                      Demir and R. Braren and S. Schwamberger and M. Lesina and J.
                      Reiser and J. Werner and T. Groll and T. Metzler and K.
                      Steiger},
      title        = {{A} porcine model of acute necrotizing pancreatitis.},
      journal      = {Pancreatology},
      volume       = {25},
      number       = {8},
      issn         = {1424-3903},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2025-01657},
      pages        = {1426-1433},
      year         = {2025},
      note         = {2025 Dec;25(8):1426-1433},
      abstract     = {Acute necrotizing pancreatitis is a common disease in
                      humans and leads to significant and world-wide morbidity and
                      mortality. Exploration of new pharmaceutical agents for the
                      treatment of this disease frequently rests on rodent models
                      that may not be relevant for spontaneous human disease and
                      also preclude collecting multiple blood samples. Goal of
                      this project was to establish an experimental model for
                      acute necrotizing pancreatitis in pigs that mirrors the
                      development of systemic complications of acute pancreatitis
                      in humans as a prelude to clinical trials in humans.The
                      accessory pancreatic duct was surgically isolated in
                      domestic pigs and 8 μmol/kg glycodeoxycholic acid were
                      slowly injected into the duct, followed by ligation and
                      cutting the duct. Pigs were repeatedly evaluated clinically
                      and multiple blood samples were collected before the pigs
                      were sacrificed and their organs histopathologically
                      assessed after 1, 5, or 7 days.All pigs showed clinical and
                      clinical pathological evidence of pancreatitis after
                      induction of pancreatitis. Pigs showed histopathological
                      evidence of acute necrotizing pancreatitis one day after
                      induction of pancreatitis. At 7 days after induction of
                      pancreatitis, dramatic regeneration could be observed in the
                      pancreas. At 5 days after induction of pancreatitis,
                      evidence of necrotizing pancreatitis was present with less
                      evidence of regeneration.The porcine model for acute
                      necrotizing pancreatitis described here shows many parallels
                      to spontaneous human disease and its systemic complications
                      and may thus serve as a good model to assess the efficacy of
                      novel pharmaceutical agents for the treatment of acute
                      pancreatitis in humans.},
      keywords     = {Acute respiratory distress syndrome (Other) / Alveolar
                      damage (Other) / Glycodeoxycholic acid (Other) / Pancreatic
                      necrosis (Other) / Systemic inflammatory response syndrome
                      (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40783359},
      doi          = {10.1016/j.pan.2025.07.415},
      url          = {https://inrepo02.dkfz.de/record/303444},
}